Olfactory dysfunction in the APP/PS1 transgenic mouse model of Alzheimer's disease: Morphological evaluations from the nose to the brain

作者

Yao, ZG;Hua, F;Zhang, HZ;Li, YY;Qin, YJ

作者单位

[Yao, Zhi-Gang; Zhang, Hao-Zhuang; Li, Yan-Yan; Qin, Ye-Jun] Shandong Univ, Dept Pathol, Shandong Prov Hosp, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.;-;[Hua, Fang] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing, Peoples R China.;-;[Hua, Fang] Peking Union Med Coll, Beijing, Peoples R China.

摘要

Olfactory dysfunction is among the signs of Alzheimer's disease (AD) and cognitive impairment. It has been demonstrated A was associated with olfactory impairment observed in both transgenic mice and in AD patients. In this study, we evaluated amyloid deposition in the olfactory circuit of APP/PS1 transgenic mouse model of AD, which showed olfactory dysfunction in olfactory behavior tests. We found amyloid depositions were widely distributed in the whole olfactory circuit. Moreover, we think these amyloid depositions contribute to neuronal atrophy, dendritic abnormalities, synapse loss and axonal degeneration. Therefore, there was a correlation between olfactory deficits and amyloid deposition. Our findings provide initial insights into the pathological basis of AD-related olfactory dysfunction.

关键词

ENTORHINAL CORTEX ACTIVITY; AMYLOID-BETA; NASAL CAVITY; BULB; EPITHELIUM; MICE; CELLS; INTERNEURONS; DEPOSITION; DEMENTIA

基本信息

所属机构:病理

归属医师: 姚志刚覃业军

PMID：28643854

UT：000417582900001

刊名:NEUROPATHOLOGY

年，卷(期):2017年37卷6期

页码：485-494

DOI：10.1111/neup.12391

附件：

收录: SCIE