MicroRNA-138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9
作者
作者单位
摘要
An accumulating number of studies have reported that the expression levels of microRNAs (miRNAs/miRs) are dysregulated in a variety of human cancer types, including renal cell carcinoma (RCC). miRNAs play essential functions in tumorigenesis and the progression of tumors by serving as oncogenes or tumor suppressors. Recently, the expression and functions of miR-138 have been studied in a number of human cancer types; however, its role in RCC remains poorly understood. In the present study, the results revealed that miR-138 was significantly downregulated in RCC cell lines and tissues, and that low expression levels of miR-138 were correlated with histological grade, tumor stage and lymph node metastasis. In functional studies, restoration of miR-138 expression inhibited cell proliferation and invasion of ACHN and A498 cells. In addition, SOX9 was validated as a direct target gene of miR-138 in RCC. SOX9 knockdown inhibited cell proliferation and invasion of RCC, with a similar effect to that induced by miR-138, rendering SOX9 a functional target of miR-138 in the disease. These findings indicate that miR-138 may present a novel target for therapeutic strategies in RCC.
关键词
HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; DOWN-REGULATION; LUNG-CANCER; CYCLIN D3; MIR-138; METASTASIS; PRINCIPLES; MECHANISM; THERAPY
基本信息
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所属机构:肾移植外科门诊
归属医师: 胡波 金讯波
UT：000417293400176
刊名:ONCOLOGY LETTERS
年，卷(期):2017年14卷6期
页码：7583-7588
DOI：10.3892/ol.2017.7160
附件：
收录: SCIE
