Subcellular localization of beta-arrestin1 and its prognostic value in lung adenocarcinoma
作者
Li, XW;Che, KY;Wang, LG;Zhang, TH;Wang, GH;Pang, ZF;Shen, HC;Du, JJ
作者单位
[Che, Keying; Pang, Zhaofei; Du, Jiajun] Shandong Univ, Shandong Prov Hosp, Inst Oncol, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.;-;[Li, Xiaowei] Shandong Univ, Shandong Prov Hosp, Dept Anesthesiol, Jinan, Shandong, Peoples R China.;-;[Wang, Liguang; Zhang, Tiehong; Shen, Hongchang] Shandong Univ, Shandong Prov Hosp, Dept Oncol, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.;-;[Wang, Guanghui; Du, Jiajun] Shandong Univ, Shandong Prov Hosp, Dept Thorac Surg, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
摘要
-Arrestins play important roles in cancer progression, and the subcellular localization of -arrestin1 has been receiving increasingly more attention. Intriguingly, several studies, including some of our previous work, showed that the effects of -arrestin1 on outcomes of cancer patients were controversial.Specimens were obtained from 133 patients with lung adenocarcinoma. Immunohistochemistry was used to detect the expression of -arrestin1 and p300 in the collected tissues. The Kaplan-Meier analysis and Cox proportional hazards regression were used to examine the relationship between -arrestin1 and patient survival.We found no significant association between -arrestin1 and clinicopathological variables. The Kaplan-Meier plot showed that patients with high expression of -arrestin1 (especially in the nucleus) had a poorer overall survival (OS) and shorter disease-free survival (DFS) (P=.026, P=.015). Additionally, high p300 expression also resulted in worse OS (P=.039). Following the univariate analysis, high expressions of nuclear -arrestin1 and p300 were classed as poor prognostic factors for both OS (P=.016) and DFS (P=.025).The expression of -arrestin1 in the nucleus is associated with increased malignant tendency of lung adenocarcinoma, and the predictive value of -arrestin1 may be optimized by combining information about the expression of p300 acetyltransferase.
关键词
NUCLEAR EXPORT SIGNAL; BETA-ARRESTINS; HIGH EXPRESSION; BREAST-CANCER; UNFAVORABLE PROGNOSIS; PROSTATE-CANCER; POOR-PROGNOSIS; P300; GROWTH; PROGRESSION
基本信息
