Optimal managements of stage IIIA (N2) non-small cell lung cancer patients: a population-based survival analysis

作者

Pang, ZF;Yang, YF;Ding, N;Huang, CC;Zhang, TH;Ni, Y;Du, JJ;Liu, Q

作者单位

[Pang, Zhaofei; Yang, Yufan; Ding, Nan; Huang, Cuicui; Du, Jiajun; Liu, Qi] Shandong Univ, Shandong Prov Hosp Affiliated, Inst Oncol, Jinan 250021, Shandong, Peoples R China.;-;[Zhang, Tiehong; Ni, Yang] Shandong Univ, Shandong Prov Hosp Affiliated, Dept Oncol, Jinan 250021, Shandong, Peoples R China.;-;[Du, Jiajun] Shandong Univ, Shandong Prov Hosp Affiliated, Dept Thorac Surg, Jinan 250021, Shandong, Peoples R China.

摘要

Background: This study aimed to investigate the optimal management of stage IIIA (cN2) non-small cell lung cancer (NSCLC) patients and determine potential predictive factors.;-;Methods: We extracted patients diagnosed as NSCLC stage IIIA (cN2) between 2004 and 2011 from Surveillance, Epidemiology, and End Results (SEER) database. Overall survival (OS) and lung cancer-specific survival (LCSS) were compared among patients given different clinical managements by Kaplan-Meier method. Other variables such as age, sex and tumor size were analyzed to explore the factors associated with outcomes.;-;Results: A total of 98,700 IIIA-cN2 NSCLC patients were identified from SEER database. Survival of patients treated with surgery was better than that of patients treated by radiotherapy alone (P<0.001). Radiation prior to surgery significantly improved the survival in comparison with surgery alone (P<0.001). In the subgroups of OS analysis, age > 65 (P=0.902), adenocarcinoma (P=0.279), tumor size =3 cm (P=0.170), well differentiated (P=0.360) patients, preoperative radiotherapy improved survival insignificantly compared with surgery alone.;-;Conclusions: Preoperative radiation with surgery had the most encouraging survival outcomes in stage IIIA-cN2 NSCLC patients compared with radiation or surgery alone. No significant outcome improvement was shown between postoperative radiotherapy (PORT) and surgery alone.

关键词

RANDOMIZED CONTROLLED-TRIAL; POSTOPERATIVE RADIOTHERAPY; INDUCTION CHEMOTHERAPY; SURGICAL RESECTION; PREOPERATIVE CHEMOTHERAPY; TNM-CLASSIFICATION; 7TH EDITION; TUMOR SIZE; PHASE-III; SURGERY

基本信息

所属机构:

归属医师: 杜贾军张铁红倪阳

UT：000417752900142

刊名:JOURNAL OF THORACIC DISEASE

年，卷(期):2017年9卷10期

页码：4046-4056

DOI：10.21037/jtd.2017.10.47

附件：

收录: SCIE