Hollow double-layered polymer nanoparticles with S-nitrosothiols for tumor targeted therapy

作者

Liu, TW;Hu, JJ;Ma, XY;Kong, B;Wang, JL;Zhang, ZD;Guo, DS;Yang, XL

作者单位

[Liu, Tuanwei; Hu, Jingjing; Ma, Xiaoye; Zhang, Zhide; Guo, Dian-Shun] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Collaborat Innovat Ctr Functionalized Probes Chem, Key Lab Mol & Nano Probes,Minist Educ, Jinan 250014, Shandong, Peoples R China.;-;[Kong, Bing] Shandong Maternal & Child Hlth Hosp, Dept Anesthesiol, Jinan 250014, Shandong, Peoples R China.;-;[Wang, Jilan] Shandong Univ, Dept Anesthesiol, Shandong Provincal Hosp, Jinan 250014, Shandong, Peoples R China.;-;[Yang, Xinlin] Nankai Univ, Key Lab Funct Polymer Mat, Minist Educ, Inst Polymer Chem,Coll Chem, Tianjin 300071, Peoples R China.

摘要

Tumor targeted hollow double-layered polymer nanoparticles (HDPNs) with S-nitrosothiols for nitric oxide (NO)-release as chemotherapy were described. Via a two-stage distillation precipitation co-polymerization, simple post-treatment and S-nitrosothiol modification, the S-nitroso HDPNs showed pH and glucose dual responsiveness. This would benefit accurate binding with the sialic acid over-expressed cancer cells, providing prerequisites for the disulfide polymer assisted cell uptake, intracellular GSH induced decomposition and rapid NO release. Confocal microscopy and cytotoxicity assay with normal versus tumor cells demonstrated in vitro recognition, intracellular delivery ability and tumor cell targeting cytotoxicity. Especially worth mentioning, the inevitable small amount of NO leakage in the transmission would take part in normal physiological activities and not cause serious side effects, providing a possible solution to avoid the intolerable side effects of traditional chemotherapy treatments for cancer.

关键词

NITRIC-OXIDE RELEASE; DRUG-DELIVERY; PHENYLBORONIC ACID; ANTICANCER DRUG; CANCER-CELLS; STIMULI; GLUTATHIONE; DONOR; NO; NANOHYDROGELS

基本信息

所属机构:

归属医师: 王继岚

UT：000411442600007

刊名:JOURNAL OF MATERIALS CHEMISTRY B

年，卷(期):2017年5卷36期

页码：7519-7528

DOI：10.1039/c7tb01715d

附件：

收录: SCIE