APC hypermethylation for early diagnosis of colorectal cancer: a meta-analysis and literature review

作者

Liang, TJ;Wang, HX;Zheng, YY;Cao, YQ;Wu, XY;Zhou, X;Dong, SX

作者单位

[Liang, Tie-Jun] Shandong Univ, Shandong Prov Hosp, Dept Digest Dis, Jinan, Shandong, Peoples R China.;-;[Wang, Hong-Xu] Jiyang Peoples Hosp, Dept Gen Surg, Jiyang, Shandong, Peoples R China.;-;[Zheng, Yan-Yan] Jiyang Peoples Hosp, Dept Med Imaging, Jiyang, Shandong, Peoples R China.;-;[Cao, Ying-Qing] Taian City Cent Hosp, Dept Anus & Intestine Surg, Tai An, Shandong, Peoples R China.;-;[Wu, Xiaoyu] Nanjing Med Univ, Dept Surg Oncol, Affiliated Hosp, Nanjing, Jiangsu, Peoples R China.;-;[Zhou, Xin] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Canc Hosp, Dept Gen Surg, Nanjing, Jiangsu, Peoples R China.;-;[Dong, Shu-Xiao] Linyi Peoples Hosp, Dept Gastrointestinal Surg, Linyi, Shandong, Peoples R China.

摘要

Adenomatous polyposis coli (APC) promoter hypermethylation has been frequently observed in colorectal cancer (CRC). The association between APC promoter methylation and clinicopathological significance in CRC is under investigation. We performed a meta-analysis to quantitatively evaluate the significance of APC methylation in CRC. The study included a total of 24 articles and 2025 CRC patients. The frequency of APC promoter hypermethylation was significantly higher in colorectal adenoma than in normal colorectal tissue, OR was 5.76, 95% CI, 2.45-13.56; p<0.0001, I-2=0%. APC promoter more frequently hypermethylated in CRC stage I compared to normal colorectal tissue, OR was 13.42, 95% CI, 3.66-49.20; p<0.0001, I-2=31%. The risk of incidence of CRC was significantly correlated to APC promoter hypermethylation, pooled OR was 9.80, 95% CI, 6.07-15.81; p<0.00001, I-2=43%. APC methylation was not associated with grade, stage of CRC as well as tumor location, patients' gender, and smoking behavior. The results indicate that APC promoter hypermethylation is an early event in carcinogenesis of CRC, could be a valuable diagnostic marker for early-stage CRC. APC methylation is not significantly associated with overall survival in patients with CRC. APC is a potential drug target for development of personalized treatment.

关键词

CPG-ISLAND HYPERMETHYLATION; TUMOR-RELATED GENES; PROMOTER METHYLATION; MICROSATELLITE INSTABILITY; CHROMOSOMAL ALTERATIONS; MOLECULAR-GENETICS; EPIGENETIC CHANGES; DNA METHYLATION; COLON CANCERS; MUTATIONS

基本信息

所属机构:保健消化内科

归属医师: 梁铁军

PMID：28515349

UT：000405504600124

刊名:ONCOTARGET

年，卷(期):2017年8卷28期

页码：46468-46479

DOI：10.18632/oncotarget.17576

附件： pdf

收录: SCIE