Copeptin and NT-proBNP for prediction of all-cause and cardiovascular death in ischemic stroke

作者

Tu, WJ;Ma, GZ;Ni, Y;Hu, XS;Luo, DZ;Zeng, XW;Liu, Q;Xu, TT;Yu, L;Wu, BS

作者单位

[Tu, Wen-Jun; Liu, Qiang] China Acad Med Sci, Inst Radiat Med, Tianjin, Peoples R China.;-;[Tu, Wen-Jun; Liu, Qiang] Peking Union Med Coll, Tianjin, Peoples R China.;-;[Tu, Wen-Jun; Hu, Xia-Sheng] China Rehabil Researcher Ctr, Dept Neurol, Beijing, Peoples R China.;-;[Ma, Guo-Zhao; Luo, Ding-Zhen] Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Peoples R China.;-;[Ni, Ying; Zeng, Xian-Wei; Xu, Tingting] Weifang Med Coll, Affiliated Hosp, Dept Neurosurg, Weifang, Peoples R China.;-;[Yu, Lie] Harbin Med Univ, Affiliated Hosp 4, Dept Emergency, Harbin, Peoples R China.;-;[Wu, Boshui] Jilin Univ, Affiliated Hosp 2, Dept Neurol, Changchun, Peoples R China.

摘要

Objective: To evaluate long-term mortality in patients with acute ischemic stroke (AIS) by exploring the correlation between death and plasma concentrations of copeptin and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in a cohort study.;-;Methods: In a prospective, multicenter observational study of 4,215 patients with AIS, copeptin and NT-proBNP levels were measured with a standardized method when patients were admitted to hospital. The primary endpoint was all-cause mortality or cardiovascular disease (CVD) mortality within 1 year.;-;Results: During a follow-up period, 906 patients (20.1%, 95% confidence interval [CI] 18.9-21.2) died, including 589 cases of CVD mortality (13.1%, 95% CI 12.1-14.0). With the use of a multivariate analysis, both markers were found to have prognostic value in the same model (CVD mortality: odds ratio [OR] for fourth quartile of copeptin and NT-proBNP 1.68 and 2.58, 95% CI 1.22-2.49 and 1.76-4.05, respectively; all-cause mortality: OR for fourth quartile of copeptin and NT-proBNP 1.48 and 2.47, 95% CI 1.22-2.03 and 1.68-3.95, respectively). In a receiver operating characteristics analysis of CVD mortality, the area under the curve varied from 0.80 to 0.83 (95% CI 0.79-0.87) when the index of NT-proBNP was added and increased to 0.86 (95% CI 0.83-0.90) when both markers were added.;-;Conclusions: Copeptin and NT-proBNP may be useful independent prognostic markers of allcause or CVD mortality in Chinese patients with AIS.

关键词

NATRIURETIC PEPTIDE LEVELS; ARGININE-VASOPRESSIN; ATRIAL-FIBRILLATION; PROGNOSTIC MARKER; CAUSE MORTALITY; HEART-FAILURE; INFARCTION; RISK; BIOMARKERS; COMMUNITY

基本信息

所属机构:

归属医师: 罗鼎真

PMID：28424274

UT：000401228300008

刊名:NEUROLOGY

年，卷(期):2017年88卷20期

页码：1899-1905

DOI：10.1212/WNL.0000000000003937

附件：

收录: SCIE