An Improved and Efficient Process for the Production of Highly Pure Dexmethylphenidate Hydrochloride

作者

Xing, LX;Shen, CW;Sun, YY;Huang, L;Zheng, YY;Li, JQ

作者单位

[Xing, Long-Xuan; Sun, Yuan-Yuan; Huang, Lei; Zheng, Yong-Yong; Li, Jian-Qi] Shanghai Inst Pharmaceut Ind, Novel Technol Ctr Pharmaceut Chem, 1111 North Zhongshan 1 Rd, Shanghai 200437, Peoples R China.;-;[Shen, Cheng-Wu] Shandong Univ, Dept Pharm, Shandong Prov Hosp, Jinan 250021, Peoples R China.

摘要

The present work describes an efficient and commercially viable process for the synthesis of dexmethylphenidate hydrochloride (1), a mild nervous system stimulant. The overall yield is 23% with similar to 99.9% purity (including seven chemical steps). Formation and control of possible impurities are also described in this report.

关键词

METHYLPHENIDATE; DERIVATIVES

基本信息

所属机构:

归属医师: 沈承武

UT：000397563000057

刊名:JOURNAL OF HETEROCYCLIC CHEMISTRY

年，卷(期):2017年54卷2期

页码：1298-1303

DOI：10.1002/jhet.2705

附件：

收录: SCIE