Insulin-like growth factor 1 and metabolic parameters are associated with nonalcoholic fatty liver disease in obese children and adolescents
作者
作者单位
摘要
Aim: Few studies have investigated the relationship between paediatric nonalcoholic fatty liver disease (NAFLD) and insulin-like growth factor 1 (IGF-1). This study, carried out from July 2013 to September 2015, aimed to fill the gap and added metabolic parameters to the analysis.;-;Methods: This was a cross-sectional study of 168 obese children and adolescents (84% male), divided into two groups based on the presence (n = 90) or absence (n = 78) of NAFLD. All participants underwent clinical examinations, anthropometric and laboratory examinations and liver ultrasonography.;-;Results: Nonalcoholic fatty liver disease patients had significantly lower IGF-1 standard deviation score (IGF-1 SDS) and higher body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and uric acid levels than the control group. The prevalence rate of NAFLD was negatively correlated with the IGF-1 SDS. IGF-1 SDS was negatively associated with NAFLD, while BMI, HOMA-IR and uric acid were positively associated with NAFLD. The combined analysis of the area under the receiver operating characteristic curve for multiple variables, including IGF-1 SDS, BMI, HOMA-IR and uric acid, was 0.812, with a sensitivity of 78.89% and specificity of 74.36%.;-;Conclusion: IGF-1, BMI, HOMA-IR and uric acid were useful markers of NAFLD in obese children and adolescents.
关键词
I IGF-I; HEPATIC STEATOSIS; PUBERTAL CHANGES; STEATOHEPATITIS; HORMONE; PATTERN; MODEL; MASS; GH
基本信息
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所属机构:
归属医师: 李桂梅 胡艳艳
PMID：27889912
UT：000397337100020
刊名:ACTA PAEDIATRICA
年，卷(期):2017年106卷2期
页码：298-303
DOI：10.1111/apa.13685
附件：
收录: SCIE
