Tip60: Main Functions and Its Inhibitors

作者

Zhang, XL;Wu, JY;Luan, YP

作者单位

[Zhang, Xiaoli; Wu, Jiyong] Shandong Univ, Dept Pharm, Prov Hosp, Jinan, Shandong, Peoples R China.;-;[Luan, Yepeng] Qingdao Univ, Dept Med Chem, Sch Pharm, Qingdao, Shandong, Peoples R China.

摘要

Background: Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates.;-;Results: Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers.;-;Conclusion: Here, main functions and its known inhibitors were summarized.

关键词

DOUBLE-STRAND BREAKS; HISTONE ACETYLTRANSFERASE ACTIVITY; ANDROGEN RECEPTOR COACTIVATORS; TELANGIECTASIA MUTATED KINASE; DEPENDENT PROTEIN-KINASE; ACETYL TRANSFERASE TIP60; DNA-DAMAGE; PROSTATE-CANCER; LYSINE ACETYLTRANSFERASES; IONIZING-RADIATION

基本信息

所属机构:中药房

归属医师: 张晓莉

PMID：27670582

UT：000402475700004

刊名:MINI-REVIEWS IN MEDICINAL CHEMISTRY

年，卷(期):2017年17卷8期

页码：675-682

DOI：10.2174/1389557516666160923125031

附件：

收录: SCIE