Brainstem injury associated with supratentorial lesions is revealed by electronystagmography of the cold caloric reflex test

作者

Fu, QZ;Qi, ZG;Yang, RR;Cheng, K;Yang, YT;Xie, P

作者单位

[Fu, Qizhi] Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Neurol, Luoyang, Peoples R China.;-;[Fu, Qizhi] Henan Univ Sci & Technol, Coll Clin Med, Luoyang, Peoples R China.;-;[Qi, Zhiguo] Jiamusi Univ, Affiliated Hosp 1, Dept Neurol, Jiamusi, Peoples R China.;-;[Yang, Ruirui] Shandong Prov Hosp, Dept Neurol, Jinan, Peoples R China.;-;[Cheng, Ke; Yang, Yongtao] Chongqing Med Univ, Inst Neurosci, Chongqing, Peoples R China.;-;[Xie, Peng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China.

摘要

To explore the brainstem injury associated with supratentorial lesions, we conducted analysis of ICP levels and detected ENG parameters by using the cold caloric reflex test and histopathological examinations of the brainstem. Rat model of intracerebral hemorrhage was well-established in the study of supratentorial lesions of varying severities (n=210). Intracerebral pressure monitoring and electronystagmography of the cold caloric reflex test were simultaneously performed in animals. Apoptotic, immunohistochemical, and histopathological changes in different segments of the brainstem were investigated at various time intervals. Electronystagmography parameters were analyzed by cold caloric reflex test. The result showed that the increase of intracerebral pressure was correlated with lesion severity including elevating levels and rostral-caudal progression of neuronal apoptosis, demyelination, N-methyl-D-aspartate cell receptor down-regulation (r=0.815), and histopathological changes. Mutiple discrimination analysis of electronystagmography parameters presented a diagnostic accuracy rate of 79.5% in localizing brainstem injury. In conclusion, our data demonstrated that electronystagmography monitoring along with the cold caloric reflex test performed a favorable effect on the estimation of brainstem injury in ICH rat model, which provided a potential bedside diagnostic tool to assess and predict the progress of supratentorial lesion patient in future.

关键词

DEATH; HERNIATION; MOVEMENTS; NYSTAGMUS; DIAGNOSIS; ISCHEMIA

基本信息

所属机构:

归属医师: 杨瑞瑞

PMID：28559965

UT：000402268600007

刊名:AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

年，卷(期):2017年9卷5期

页码：2119-+

附件： pdf

收录: SCIE