Overexpression of OCT4 is associated with gefitinib resistance in non-small cell lung cancer
作者
Li, B;Yao, ZH;Wan, YY;Lin, DJ
作者单位
[Li, Bin; Yao, Zhouhong; Wan, Yunyan; Lin, Dianjie] Shandong Univ, Shandong Prov Hosp, Dept Resp Med, Jinan 250021, Shandong, Peoples R China.
摘要
Epidermal growth factor receptor (EGFR)-targeted tyrosine kinase inhibitors (TKIs) have emerged as first-line drugs for non-small cell lung cancers (NSCLCs). However, the resistance to TKIs represents the key limitation for their therapeutic efficacy. We found that the difference of OCT4 expression between NSCLC and the adjacent non-tumourous tissues was statistically significant. Knockdown of OCT4 in NSCLC cells could decrease cell proliferation, and potentiate apoptosis induced by gefitinib, suggesting OCT4 may contribute to gefitinib resistance in NSCLC.
关键词
EXPRESSION; EGFR; MUTATION; DOMAIN
基本信息
