Spleen Stiffness Is Superior to Liver Stiffness for Predicting Esophageal Varices in Chronic Liver Disease: A Meta-Analysis
作者
Ma, XW;Wang, L;Wu, H;Feng, YM;Han, XB;Bu, HR;Zhu, Q
作者单位
[Ma, Xiaowen; Wang, Le; Wu, Hao; Feng, Yuemin; Bu, Haoran; Zhu, Qiang] Shandong Univ, Shandong Prov Hosp, Dept Gastroenterol, Jinan, Shandong, Peoples R China.;-;[Ma, Xiaowen; Wang, Le; Wu, Hao; Feng, Yuemin; Bu, Haoran; Zhu, Qiang] Shandong Prov Engn & Technol Res Ctr Liver Dis Pr, Jinan, Shandong, Peoples R China.;-;[Han, Xibiao] Shandong Univ, Shandong Prov Hosp, Dept Pharm, Jinan, Shandong, Peoples R China.
摘要
Background and Aims;-;Liver stiffness (LS) and spleen stiffness (SS) are two most widely accessible non-invasive parameters for predicting esophageal varices (EV), but the reported accuracy of the two predictors have been inconsistent across studies. This meta-analysis aims to evaluate the diagnostic performance of LS and SS measurement for detecting EV in patients with chronic liver disease (CLD), and compare their accuracy.;-;Methods;-;Pubmed/Medline, Embase, Cochrane Library and Ovid were searched for all studies assessing SS and LS simultaneously in EV diagnosis. A total of 16 studies including 1892 patients were included in this meta-analysis, and the pooled statistical parameters were calculated using the bivariate mixed effects models.;-;Results;-;In detection of any EV, for LS measurement, the summary sensitivity was 0.83 (95% confidence interval [CI]: 0.78-0.87), and the specificity was 0.66 (95% CI: 0.60-0.72). While for SS measurement, the pooled sensitivity and specificity was 0.88 (95% CI: 0.83-0.92) and 0.78 (95% CI: 0.73-0.83). The summary receiver operating characteristic (SROC) curve values of LS and SS were 0.81 (95% CI: 0.77-0.84) and 0.88 (95% CI: 0.85-0.91) respectively, and the results had statistical significance (P<0.01). The diagnostic odds ratio (DOR) of SS (25.73) was significantly higher than that of LS (9.54), with the relative DOR value was 2.48 (95% CI: 1.10-5.60), P<0.05.;-;Conclusions;-;Under current techniques, SS is significantly superior to LS for identifying the presence of EV in patients with CLD. SS measurement may help to select patients for endoscopic screening.
关键词
SIGNIFICANT PORTAL-HYPERTENSION; TRANSIENT ELASTOGRAPHY; GASTROESOPHAGEAL VARICES; DIAGNOSTIC-ACCURACY; CIRRHOTIC-PATIENTS; SHEAR-WAVE; NONINVASIVE ASSESSMENT; ARFI ELASTOGRAPHY; HEPATITIS; RISK
基本信息
