NLRP2 is highly expressed in a mouse model of ischemic stroke

作者

Sun, X;Song, X;Zhang, L;Sun, J;Wei, XB;Meng, LY;An, J

作者单位

[Sun, Xia; Song, Xiao; Sun, Jian; Wei, Xinbing; An, Jie] Shandong Univ, Sch Med, Dept Pharmacol, 44 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.;-;[Zhang, Li] Shandong Univ, Prov Hosp, Dept Gastrointestinal Surg, Jinan 250021, Shandong, Peoples R China.;-;[Meng, Liya] Shandong Univ, Affiliated Hosp 2, Dept Dermatol, Jinan 250033, Shandong, Peoples R China.

摘要

Nucleotide binding oligomerization domain (NOD)-like receptors (NLRs) are a class of cytoplasmic pattern-recognition receptors with a major role in innate immunity. Fourteen of the twenty-two human NLRs contain a pyrin domain and form the NLRP subfamily (NLRPs). Among NLRPs, NLRP2 is less well understood in aspects of distribution and functions, especially in central nervous system (CNS). This study was the first to explore the expression of NLRP2 in central nervous system both under normal conditions and in ischemic stroke models. We found NLRP2 protein had a basal level of expression in CNS, mainly in astrocytes and was significantly elevated in ischemic brains in vivo or oxygen-glucose deprivation-treated cells in vitro. And silencing of NLRP2 genes could reduce the apoptotic rate of oxygen-glucose deprivation-treated cells. Thus high expression of NLRP2, especially in astrocytes, may play important roles in the pathophysiological process of ischemic stroke and has potential clinical value for the treatment of ischemic stroke. (C) 2016 Elsevier Inc. All rights reserved.

关键词

INFLAMMASOME; ASSOCIATION; MICROGLIA; DISEASES; SYSTEM; INJURY; BETA

基本信息

所属机构:

归属医师: 张黎

PMID：27693696

UT：000387200300009

刊名:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

年，卷(期):2016年479卷4期

页码：656-662

DOI：10.1016/j.bbrc.2016.09.157

附件：

收录: SCIE