Caveolin-1 is overexpressed in hypopharyngeal squamous cell carcinoma and correlates with clinical parameters
作者
Zhao, XN;Yu, G;Yu, XM;Wang, J;Pan, XL
作者单位
[Zhao, Xuening; Yu, Gang] Shandong Univ, Dept Comprehens Hlth 2, Shandong Prov Hosp, 324 Jingwu St, Jinan 250021, Shandong, Peoples R China.;-;[Yu, Xuemin; Wang, Juan; Pan, Xinliang] Shandong Univ, Dept Otolaryngol, Qilu Hosp, Jinan 250031, Shandong, Peoples R China.
摘要
The present study aimed to identify the role of caveolin-1 (CAV1) in hypopharyngeal squamous cell carcinoma (HSCC) and identify its possible correlation with tumor clinical parameters. Expression of CAV1 was measured using immunohistochemical staining of 66 HSCC samples and 44 samples from morphologically normal tissues adjacent to the carcinomas. Expression of CAV1 in HSCC and paracancerous tissues were 71.2 and 9.5% respectively. Levels of CAV1 expression were significantly associated with tumor differentiation, tumor-node-metastasis stage and lymph nodes metastasis (P<0.05). The present study identified that expression of CAV1 in HSCC is significantly higher than in paracancerous tissues, suggesting that this high expression of CAV1 is associated with tumor invasion and metastasis.
关键词
PROSTATE-CANCER; LIPID RAFTS; EXPRESSION; GROWTH; BREAST; INHIBITION; DOMAINS; GENE
基本信息
