Thyroxine therapy ameliorates serum levels of eicosanoids in Chinese subclinical hypothyroidism patients
作者
Zhang, Y;Zhang, BC;Xu, J;Zhao, M;Wang, Z;Song, YF;Zhang, HQ;Gao, L;Zhang, QY;Zhao, JJ
作者单位
[Zhang, Yan; Zhang, Bing-chang; Xu, Jin; Zhao, Meng; Wang, Zhe; Song, Yong-feng; Zhang, Hai-qing; Gao, Ling; Zhao, Jia-jun] Shandong Univ, Shandong Prov Hosp, Div Endocrinol & Metab, Jinan 250021, Peoples R China.;-;[Zhang, Yan] Baoshan Hosp Integrated Tradit Chinese & Western, Shanghai 201900, Peoples R China.;-;[Zhang, Qun-ye] Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250100, Peoples R China.;-;[Zhang, Qun-ye] Shandong Univ, Qilu Hosp, Chinese Minist Hlth, Jinan 250100, Peoples R China.;-;[Zhang, Qun-ye] Shandong Univ, Qilu Hosp, State & Shandong Prov Joint Key Lab Translat Card, Jinan 250100, Peoples R China.;-;[Zhang, Qun-ye] Shandong Univ, Hosp 2, Cent Res Lab, Jinan 250100, Peoples R China.
摘要
Aim: The eicosanoids derived from phospholipids play key roles in inflammation. However, the profiles of serum eicosanoids in subclinical hypothyroidism (SH) patients and the effects of thyroxine replacement therapy (TRT) on these eicosanoids remain unclear. Many studies show that TSH regulates lipid metabolism. As eicosanoids derived from phospholipids play key roles in oxidative stress and immune function and inflammatory process, it was necessary to explore the profiles of serum eicosanoids in SH patients and the effects of thyroxine replacement therapy (TRT) on the eicosanoids.;-;Methods: A total of 50 Chinese SH patients and 22 healthy volunteers were recruited. SH patients received TRT (L-T4, 25 and 50 mcg/d for patients with TSH <= 10.0 mIU/L and TSH>10.0 mIU/L, respectively) for 3 months. Serum levels of major eicosanoids and cPLA2 were analyzed using LC-MS and clinical biochemical assays.;-;Results: The serum levels of cPLA2, eicosanoids (8-isoPGF2a, 11-dehydroTXB2 and 12-HETE) and 11-dehydroTXB2/6-Keto-PGF1a were significantly elevated in SH patients. The serum TSH levels were significantly correlated with the levels of cPLA2 (r=+0.65), 11-dehydroTXB2 (r=+0.32) and 11-dehydroTXB2/6-Keto-PGF1a (r=+0.37). After 3-month TRT, the serum levels of TSH, cPLA2 and the above-mentioned eicosanoids in SH patients were significantly decreased.;-;Conclusion: The metabolism of eicosanoids is significantly altered in Chinese SH patients, and TRT can ameliorate the abnormalities of serum eicosanoid levels.
关键词
THROMBOXANE A(2); THYROID-DYSFUNCTION; DEFICIENT MICE; ALL-CAUSE; IN-VIVO; RISK; ATHEROSCLEROSIS; REPLACEMENT; CELLS; OVERT
基本信息
