Intercellular adhesion molecule 1 is a sensitive and diagnostically useful immunohistochemical marker of papillary thyroid cancer (PTC) and of PTC-like nuclear alterations in Hashimoto's thyroiditis
作者
Zhang, K;Ge, SJ;Lin, XY;Lv, BB;Cao, ZX;Li, JM;Xu, JW;Wang, QX
作者单位
[Zhang, Ke] Shandong Univ, Shandong Prov Hosp, Dept Nucl Med, Jinan 250021, Shandong, Peoples R China.;-;[Ge, Shu-Jian] Shandong Univ, Shandong Prov Hosp, Dept Sci & Educ, Jinan 250021, Shandong, Peoples R China.;-;[Lin, Xiao-Yan; Lv, Bei-Bei; Cao, Zhi-Xin; Li, Jia-Mei; Xu, Jia-Wen; Wang, Qiang-Xiu] Shandong Univ, Shandong Prov Hosp, Dept Pathol, 324 Weiqi Ave,Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
摘要
Intercellular adhesion molecule 1 (ICAM-1) is important in the progression of inflammatory responses. Recently, increased levels of ICAM-1 have been reported in a number of types of malignancy. The present study aimed to investigate ICAM-1 expression in papillary thyroid cancer (PTC) and in Hashimoto's thyroiditis (HT) with PTC-like nuclear alterations, and to assess the predictive value of ICAM-1 in thyroid lesions. ICAM-1 expression was retrospectively investigated in 132 consecutive cases of PTC, 72 cases of HT, 10 of follicular cancer, 15 of follicular adenoma, 16 of nodular goiter and 8 samples of normal thyroid tissue using immunohistochemical analyses, and in 42 PTC patients using western blotting. ICAM-1 expression was not detected in normal follicular cells, follicular lesions (adenoma and cancer) and benign nodular hyperplasia, but was frequently overexpressed in PTC cells. ICAM-1 overexpression was associated with extra-thyroidal invasion and lymph node metastasis; no association was found with age, gender, tumor size, multifocality, pathological stage, recurrence or distant metastasis. ICAM-1 expression in HT patients with PTC-like nuclear alterations was significantly higher than that in HT cases with non-PTC-like features. Compared with antibodies against cytokeratin 19, galectin-3 and Hector Battifora mesothelial-1, ICAM-1 was the most sensitive marker for the detection of PTC-like features in HT. These findings demonstrate that ICAM-1 expression is upregulated in PTC and in HT with PTC-like nuclear alterations. This feature may be an important factor in the progression of cancer of the thyroid gland.
关键词
CARCINOMA; EXPRESSION; ICAM-1; GALECTIN-3; CELLS; MICROCARCINOMA; INVASION; FEATURES; RISK; P63
基本信息
