New synthesis route for the preparation of pomalidomide

作者

Huang, DW;Shen, CW;Wang, WY;Huang, L;Ni, F;Li, JQ

作者单位

[Huang, Daowei; Wang, Wenya; Huang, Lei; Ni, Feng; Li, Jianqi] Shanghai Inst Pharmaceut Ind, Novel Technol Ctr Pharmaceut Chem, Shanghai 201203, Peoples R China.;-;[Huang, Daowei; Wang, Wenya; Huang, Lei; Ni, Feng; Li, Jianqi] Shanghai Engn Res Ctr Pharmaceut Proc, Shanghai, Peoples R China.;-;[Shen, Chengwu] Shandong Univ, Shandong Prov Hosp, Jinan, Peoples R China.

摘要

A new route for the preparation of pomalidomide is described in the study. The synthetic procedure starts from 4-nitroisobenzofuran-1,3-dione and 3-aminopiperidine-2,6-dione hydrochloride via a three-step reaction resulting in a total yield of 65% with a high-performance liquid chromatographic (HPLC) purity of 99.56% and a low palladium residue level of 2ppm. This method can be deemed as an efficient, practical, and environmentally friendly synthetic route for the preparation of pomalidomide.;-;[GRAPHICS];-;.

关键词

REFRACTORY MULTIPLE-MYELOMA; THALIDOMIDE

基本信息

所属机构:

归属医师: 沈承武

UT：000383174200002

刊名:SYNTHETIC COMMUNICATIONS

年，卷(期):2016年46卷16期

页码：1343-1348

DOI：10.1080/00397911.2016.1189574

附件：

收录: SCIE