Interaction Between Polymorphisms of IFN-gamma and MICA Correlated with Hepatocellular Carcinoma
作者
Li, HG;Liu, FF;Zhu, HQ;Zhou, X;Lu, J;Chang, H;Hu, JH
作者单位
[Li, Hongguang; Liu, Fangfeng; Zhu, Huaqiang; Zhou, Xu; Lu, Jun; Chang, Hong] Shandong Univ, Dept Hepatobiliary Surg, Shandong Prov Hosp, Jinan 250100, Shandong, Peoples R China.;-;[Hu, Jinhua] Shandong Univ, Dept Surg Gastroenterol, Shandong Prov Hosp, Jinan 250100, Shandong, Peoples R China.
摘要
Background: We explored the relationship of interferon-gamma (IFN-gamma) and MHC class-I chain related gene A (MICA) genes polymorphisms with hepatocellular carcinoma (HCC) risk, and tried to determine whether the interaction existed between these two genes polymorphisms on the basis of HCC.;-;Material/Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect the genotypes of the 3 single-nucleotide polymorphisms (SNPs) and to analyze the correlation of each SNP with HCC susceptibility in 120 HCC patients and 124 healthy people. The association strength between the 3 SNPs and HCC is represented with odds ratio (OR) and 95% confidence interval (95% CI). Hardy-Weinberg equilibrium (HWE) was tested by x2 test in the control group.;-;Results: GG genotype of IFN-gamma rs2069727 polymorphism had apparently different distributions in case and control groups (P<0.05), and might confer increased risk of HCC (OR=3.40, 95% CI=1.23-9.38). Analysis of MICA rs2596542 polymorphism also yielded the same result (OR=2.90, 95% CI=1.10-7.67), as did their risk alleles. Specifically, the interaction between rs2596542 and rs2069705 polymorphisms increased the HCC risk by 1.41 times and between rs2596542 and rs2069727 polymorphisms the increased risk of HCC by 5.56 times.;-;Conclusions: IFN-gamma rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC. Interaction exists between the polymorphisms of IFN-gamma and MICA, which may increase risk of HCC.
关键词
CLASS-I; NKG2D LIGANDS; T-CELLS; GENE; RISK; SUSCEPTIBILITY; EXPRESSION; INDUCTION; DISEASES; IL-6
基本信息
