Protective effects of drag-reducing polymers in a rat model of monocrotaline-induced pulmonary hypertension
作者
作者单位
摘要
OBJECTIVES: Drag-reducing polymers (DRPs) are blood-soluble macromolecules which may increase blood flow and reduce vascular resistance. The purpose of the present study was to observe the effect of DRPs on monocrotaline-induced pulmonary hypertension (PH) in the rat model.;-;METHODS: A total of 64 male Wistar rats were randomly divided into four groups: Group I (pulmonary hypertension model + DRP treatment); Group II (pulmonary hypertension model + saline treatment); Group III (control + DRP treatment); Group IV (control + saline treatment). After five weeks, comparisons were made of the following indices: survival rate, body weight, blood pressure, right ventricular systolic pressure, right ventricular hypertrophy, wall thickness of pulmonary arteries, the internal diameter of small pulmonary arteries, plasma IL-1 beta and IL-6.;-;RESULTS: The survival rate after 5 weeks varied significantly across all groups (P = 0.013), but the survival rates of Groups I and II were not statistically significantly different. Administration of DRP (intravenous injection twice weekly) attenuated the PH-induced increase in right ventricular systolic pressure and suppressed the increases in right ventricular (RV) weight and the ratio of right ventricular weight to left ventricle plus septum weight (RV/LV + S). DRP treatment also significantly decreased the wall thickness of pulmonary arteries, augmented the internal diameter of small pulmonary arteries, and suppressed increases in the plasma levels of IL-1 beta and IL-6.;-;CONCLUSIONS: DRP treatment with intravenous injection effectively inhibited the development of monocrotaline-induced pulmonary hypertension in the rat model. DRPs may have potential application for the treatment of pulmonary hypertension.
关键词
HEMORRHAGIC-SHOCK; ALOE-VERA; DIAGNOSIS; SURVIVAL; REDUCTION; INFUSION; DISEASE; BLOOD
基本信息
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所属机构:
归属医师: 牟晓燕
PMID:26889655
UT:000375055900002
刊名:BIORHEOLOGY
年,卷(期):2016年53卷1期
页码:13-22
DOI:10.3233/BIR-15062
附件:
收录: SCIE