Association of AT1R polymorphism with hypertension risk: An update meta-analysis based on 28,952 subjects
作者
Liu, DX;Zhang, YQ;Hu, B;Zhang, JF;Zhao, Q
作者单位
[Liu, Dong-Xing; Hu, Bo] Shandong Univ, Shandong Prov Hosp, Emergency Dept, Jinan 250100, Peoples R China.;-;[Zhang, Yu-Qing] Peoples Hosp HuaiYin, Hlth Div, Jinan, Peoples R China.;-;[Zhang, Jianfeng; Zhao, Qiang] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Cardiac Surg, Shanghai 200025, Peoples R China.
摘要
Background: Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension. However, the results remain controversial. In the present study, we performed a meta-analysis to systematically summarize the association between AT1R genetic polymorphisms and the risk for hypertension.;-;Methods: We searched the literature in PubMed, EMBASE, ISI Web of Science, Wanfang, and Chinese National Knowledge Infrastructure databases (CNKI) to find case-control studies on the associations of AT1R genetic polymorphisms with the risk for hypertension. The meta-analysis was performed by using RevMan 5.0 software. The association of hypertension risk with AT1R genetic polymorphism was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs).;-;Results: Fifty-six studies involving 28,952 subjects were included in the present meta-analysis. Our results suggest that the polymorphism (A1166C) of AT1R gene is associated with a statistically increased hypertension risk, not only in Asian populations but also in Caucasian populations. We did not find any association in African populations.;-;Conclusions: This meta-analysis suggests that A1166C polymorphism in the AT1R gene is associated with the risk of hypertension in Asian and Caucasian populations.
关键词
II TYPE-1 RECEPTOR; RENIN-ANGIOTENSIN SYSTEM; GENE POLYMORPHISMS; ALDOSTERONE SYSTEM; A1166C POLYMORPHISM; HAN CHINESE; POPULATION; HAPLOTYPE; JAPANESE
基本信息
