Cytokine Responses to Specific Immunotherapy in House Dust Mite-Induced Allergic Rhinitis Patients

作者

Li, H;Xu, EX;He, MQ

作者单位

[Li, Hong; He, Mingqiang] Shandong Univ, Prov Hosp, Dept Otolaryngol Head & Neck Surg, Jinan 250021, Peoples R China.;-;[Xu, Enxiu] Shandong Univ, Prov Hosp, Dept Paediat, Jinan 250021, Peoples R China.

摘要

Allergen-specific immunotherapy is the only immunomodulatory treatment that may alter the natural course of allergic disease. However, cytokine responses accompanying sublingual immunotherapy (SLIT) responder phenotypes have not been fully understood. Herein, we examined the level of crucial plasma cytokines during SLIT and evaluated whether their changes correlated to symptom scores. We observed that the levels of interleukin (IL)-17 and complement components C3a and C5a as well as IL-4 at year 3 of SLIT were significantly decreased than those at baseline. In contrast, there was no significant difference in the levels of IL-5, IL-13, and interferon (IFN)-gamma. Notably, a significant positive correlation was found between the levels of IL-17 and the symptom scores at year 3. These results suggest that IL-17 could be considered a potential biomarker for the therapeutic effect of SLIT in allergic rhinitis caused by house dust mite.

关键词

SUBLINGUAL-SWALLOW IMMUNOTHERAPY; DOUBLE-BLIND; COMPLEMENT ACTIVATION; RESPIRATORY ALLERGY; ASTHMA; CELLS; METAANALYSIS; INTERLEUKIN-17; ANAPHYLATOXINS; SEVERITY

基本信息

所属机构:耳鼻咽喉科病房

归属医师: 何明强李红徐恩秀

PMID：26122703

UT：000364223800022

刊名:INFLAMMATION

年，卷(期):2015年38卷6期

页码：2216-2223

DOI：10.1007/s10753-015-0204-3

附件：

收录: SCIE