Aberrant expression of Notch1/numb/snail signaling, an epithelial mesenchymal transition related pathway, in adenomyosis
作者
Qi, SS;Zhao, XB;Li, MJ;Zhang, XH;Lu, ZZ;Yang, CR;Zhang, CH;Zhang, H;Zhang, N
作者单位
[Qi, Shasha; Zhao, Xingbo; Li, Mingjiang; Zhang, Xiaohui; Lu, Zhenzhen; Yang, Chunrun; Zhang, Chunhua; Zhang, Hui] Shandong Univ, Shandong Prov Hosp, Dept Obstet & Gynecol, Jinan 250021, Shandong, Peoples R China.;-;[Zhang, Na] Shandong Univ, Shandong Prov Hosp, Dept Anesthesiol & Surg, Jinan 250021, Shandong, Peoples R China.
摘要
Background: Epithelial mesenchymal transition (EMT) is involved in the pathogenesis of adenomyosis, and Notch signaling is crucial to EMT. The objective of this study was to explore Notch1/Numb/Snail signaling in adenomyosis.;-;Methods: The expression levels of the members of the Notch1/Numb/Snail signaling cascade in normal endometria (proliferative phase: n = 15; secretory phase: n = 15; postmenopausal phase: n = 15) and adenomyotic endometria (proliferative phase: n = 15; secretory phase: n = 15) were determined by immunohistochemistry analysis.;-;Results: We found that the expressions of Notch1 and the EMT-related proteins N-cadherin, Snail and Slug were upregulated in the ectopic endometrium of adenomyosis compared with normal endometrium. Numb, a negative regulator of Notch signaling, was significantly decreased in adenomyosis. In addition, reduced immunoexpression of E-cadherin was observed in adenomyosis.;-;Conclusions: We conclude that Notch1/Numb/Snail signaling plays an important role in the pathogenesis and development of adenomyosis.
关键词
E-CADHERIN EXPRESSION; ENDOMETRIAL STROMAL CELLS; CANCER-CELLS; TRANSCRIPTION FACTORS; PROSTATE-CANCER; CARCINOMA-CELLS; OVARIAN-CANCER; SNAIL; NUMB; NOTCH1
基本信息
