Inhibitory effect of group II mGluR agonist 2R, 4R-APDC on cell proliferation in dentate gyrus in rats with epileptic seizure
作者
Yao, H;Feng, YB;Pang, YJ;Xu, JJ;Yu, BX;Liu, XP
作者单位
[Yao, H.; Pang, Y. -J.; Xu, J. -J.; Yu, B. -X.; Liu, X. -P.] Shandong Univ, Prov Hosp, Dept Geriatr, Jinan 250100, Peoples R China.;-;[Feng, Y. -B.] Shandong Univ, Prov Hosp, Dept Neurol, Jinan 250100, Peoples R China.
摘要
OBJECTIVE: Epileptic seizure can increase the cell proliferation in dentate gyrus in brain, but the mechanism remains unclear.;-;MATERIALS AND METHODS: In this study, using systemic bromodeoxyuridine (BrdU) to label the dividing cells, the inhibitory effect of group II metabotropic glutamate receptor (mGluR) agonist 2R, 4R-4-aminopyrrolidine-2, 4-dicarboxylate (2R, 4R-APDC) on cell proliferation in dentate gyrus in rats after pilocarpine-induced status epilepticus (SE) was investigated.;-;RESULTS: Results found that, 2R, 4R-APDC could significantly inhibit the behavioral seizure and block the seizure-induced increase of BrdU-positive cells in dentate gyrus, especially in hilus. Double-label immunofluorescence staining showed that, 2R, 4R-APDC did not affect the ability of newborn cells to differentiate into neurons or astrocytes.;-;CONCLUSIONS: 2R, 4R-APDC not only has anticonvulsant effect on adult rats with pilocarpine-induced SE, but also has neuroprotective effect by reducing the abnormal regeneration of nerves.
关键词
METABOTROPIC GLUTAMATE RECEPTORS; TEMPORAL-LOBE EPILEPSY; GRANULE CELLS; ADULT-RAT; INDUCED NEUROGENESIS; BRAIN; ACTIVATION; INJURY; ANTAGONISTS; NEURONS
基本信息
