TIPE2 protein negatively regulates HBV-specific CD8(+) T lymphocyte functions in humans

作者

Zhang, WQ;Zhang, J;Zhao, LY;Shao, J;Cui, J;Guo, C;Zhu, FL;Chen, YHH;Liu, SX

作者单位

[Zhang, Wenqian; Shao, Jie; Cui, Jian; Guo, Chun; Zhu, Faliang; Liu, Suxia] Shandong Univ, Sch Med, Dept Immunol, Jinan 250100, Peoples R China.;-;[Zhang, Jiao] Shandong Univ, Prov Hosp, Dept Hepatol, Jinan 250100, Peoples R China.;-;[Zhao, Lianying] Shandong Univ, Qilu Hosp, Dept Anesthesiol, Jinan 250100, Peoples R China.;-;[Chen, Youhai H.] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA.

摘要

Cytotoxic T cell-mediated killing of virus-infected hepatocytes is an important pathogenic process of hepatitis B. However, its underlying molecular mechanisms are not fully understood. TNFAIP8L2 (TIPE2) is a newly described anti-inflammatory protein that is essential for maintaining immune homeostasis. In this study, we found that the protein levels of TIPE2 in PBMCs of hepatitis B patients were significantly reduced and negatively correlated with the sera values of aminotransferases. Importantly, TIPE2 protein was downregulated preferentially in cytotoxic CD8(+) T cells, not CD4(+) helper T cells. The CD8(+) T cells with low TIPE2 expression were more activated and produced higher levels of perforin, granzyme B, and IFN-gamma. As a result, their cytolytic activity was markedly enhanced. Interestingly, HBc(18-27) peptide stimulation could reduce TIPE2 expression in PBMCs. These results indicate that TIPE2 plays an important role in regulating HBV-specific CD8(+) T cell functions in patients with hepatitis B. (C) 2014 Elsevier Ltd. All rights reserved.

关键词

HEPATITIS-B-VIRUS; ACUTE VIRAL-HEPATITIS; IMMUNE HOMEOSTASIS; INFECTION; CELLS; RESPONSES; MICE; EXPRESSION; CLEARANCE; EPITOPES

基本信息

所属机构:

归属医师: 张娇

PMID：25499447

UT：000348256400026

刊名:MOLECULAR IMMUNOLOGY

年，卷(期):2015年64卷1期

页码：204-209

DOI：10.1016/j.molimm.2014.11.019

附件：

收录: SCIE