Correlation between CYP4F2 gene rs2108622 polymorphism and susceptibility to ischemic stroke
作者
Meng, C;Wang, J;Ge, WN;Tang, SC;Xu, GM
作者单位
[Meng, Chong] Shandong Univ, Shandong Prov Hosp, Urgent Care Ctr, Jinan 250021, Shandong, Peoples R China.;-;[Wang, Juan] Shandong Univ, Shandong Prov Hosp, Dept Resp Healthcare Med, Jinan 250021, Shandong, Peoples R China.;-;[Tang, Shao-Can] Shandong Univ, Shandong Prov Hosp, Dept Rehabil Med, Jinan 250021, Shandong, Peoples R China.;-;[Xu, Guang-Ming] Shandong Univ, Shandong Prov Hosp, Dept Neurosurgery, Jinan 250021, Shandong, Peoples R China.;-;[Ge, Wei-Ning] Qingdao Eighth Peoples Hosp, Dept Gen Surg, Qingdao 266100, Shandong, Peoples R China.
摘要
Objective: To conduct a meta-analysis for the correlation between cytochrome P450 4F2 (CYP4F2) rs2108622 (V433M) gene polymorphism and ischemic stroke. Methods: We retrieved the case-control studies on the correlation between CYP4F2 V433M polymorphism and ischemic stroke included in domestic and international databases before January 2015 and selected the best genetic model, using RevMan 5.2 software for meta-analysis. According to the heterogeneity test results of selected literature, the effect model of consolidated data was selected, and the combined OR and 95% CI were calculated. Results: A total of six documents were included. Recessive model (VM + MM vs. VV) was selected as the best genetic model. The combined results showed that: compared with wildtype VV, there are significant association between ischemic stroke and CYP4F2 polymorphism (OR merge = 1.37, 95% CI: 1.21 similar to 1.54, P < 0.001). Conclusion: CYP4F2 V433M may be the susceptibility gene for ischemic stroke.
关键词
SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD-PRESSURE; WARFARIN; METAANALYSIS; ASSOCIATION; POPULATION; EXCRETION; CYP4A11; VKORC1; CYP2C9
基本信息
