Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats
作者
Yin, QQ;Ma, YJ;Hong, Y;Hou, XY;Chen, J;Shen, C;Sun, MH;Shang, YY;Dong, SQ;Zeng, ZL;Pei, JJ;Liu, XP
作者单位
[Yin, Qingqing; Ma, Yingjuan; Hong, Yan; Hou, Xunyao; Chen, Jian; Sun, Menghan; Shang, Yuying; Dong, Siqin; Zeng, Ziling; Liu, Xueping] Shandong Univ, Prov Hosp, Dept Senile Neurol, Jinan 250021, Shandong, Peoples R China.;-;[Shen, Chao; Zeng, Ziling; Liu, Xueping] Shandong Univ, Prov Hosp, Dept Antiageing, Jinan 250021, Shandong, Peoples R China.;-;[Pei, Jin-Jing] Karolinska Inst, Res Ctr, Dept KI Alzheimer Dis, S-14186 Huddinge, Sweden.;-;[Pei, Jin-Jing] Capital Med Univ, Xuan Wu Hosp, Dept Neurol, Beijing 100053, Peoples R China.;-;[Pei, Jin-Jing] Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100053, Peoples R China.
摘要
Fructose intake is linked with the increasing prevalence of insulin resistance, and insulin resistance links Alzheimer's disease with impaired insulin signaling, oxidative damage, neuroinflammation, and cognitive impairment. As a member of the carotenoid family of phytochemicals, lycopene is used as a potent free scavenger, and has been demonstrated to be effective in anti-oxidative stress and anti-inflammatory reaction in the models of AD and other neurodegenerative diseases. Here, we investigated the effect of lycopene on learning and memory impairment and the possible underlying molecular events in fructose-drinking insulin resistant rats. We found that long-term fructose-drinking causes insulin resistance, impaired insulin signaling, oxidative stress, neuroinflammation, down-regulated activity of cholinergic system, and cognitive impairment, which could be significantly ameliorated by oral lycopene administration. The results from this study provide experimental evidence for using lycopene in the treatment of brain damage caused by fructose-drinking insulin resistance. (C) 2014 Elsevier Ltd. All rights reserved.
关键词
TYPE-2 DIABETES-MELLITUS; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; HUMAN HEALTH; MOUSE MODEL; PPAR-GAMMA; EXPRESSION; DECLINE; GROWTH; CELLS
基本信息
