Penile erectile dysfunction after brachial plexus root avulsion injury in rats

作者

Fu, G;Qin, BG;Jiang, L;Huang, XJ;Lu, QS;Zhang, DC;Liu, XL;Zhu, JK;Zheng, JW;Li, XJ;Gu, LQ

作者单位

[Fu, Guo; Qin, Bengang; Liu, Xiaolin; Zhu, Jiakai; Zheng, Jianwen; Gu, Liqiang] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Orthoped Trauma & Microsurg, Guangzhou 510080, Guangdong, Peoples R China.;-;[Jiang, Li] Sun Yat Sen Univ, Affiliated Hosp 1, Eastern Hosp, Inst Orthoped, Guangzhou 510080, Guangdong, Peoples R China.;-;[Huang, Xijun] Sun Yat Sen Univ, Affiliated Hosp 1, Eastern Hosp, Dept Upper Limb Orthoped, Guangzhou 510080, Guangdong, Peoples R China.;-;[Lu, Qinsen] Shandong Prov Hosp, Emergency Dept, Jinan, Shandong, Peoples R China.;-;[Zhang, Dechun] Binzhou Med Coll, Affiliated Hosp, Dept Orthoped, Binzhou, Shandong, Peoples R China.;-;[Li, Xuejia] Sun Yat Sen Univ, Affiliated Hosp 1, Off Res Serv, Guangzhou 510080, Guangdong, Peoples R China.

摘要

Our previous studies have demonstrated that some male patients suffering from brachial plexus injury, particularly brachial plexus root avulsion, show erectile dysfunction to varying degrees. However, the underlying mechanism remains poorly understood. In this study, we evaluated the erectile function after establishing brachial plexus root avulsion models with or without spinal cord injury in rats. After these models were established, we administered apomorphine (via a subcutaneous injection in the neck) to observe changes in erectile function. Rats subjected to simple brachial plexus root avulsion or those subjected to brachial plexus root avulsion combined with spinal cord injury had significantly fewer erections than those subjected to the sham operation. Expression of neuronal nitric oxide synthase did not change in brachial plexus root avulsion rats. However, neuronal nitric oxide synthase expression was significantly decreased in brachial plexus root avulsion + spinal cord injury rats. These findings suggest that a decrease in neuronal nitric oxide synthase expression in the penis may play a role in erectile dysfunction caused by the combination of brachial plexus root avulsion and spinal cord injury

关键词

BROWN-SEQUARD SYNDROME; NITRIC-OXIDE; SPINAL-CORD; SEXUAL DYSFUNCTION; TRACTION INJURY; ANIMAL-MODEL; PALSY; REPAIR; SATISFACTION; MECHANISMS

基本信息

所属机构:

归属医师: 路庆森

PMID：25422647

UT：000344637400009

刊名:NEURAL REGENERATION RESEARCH

年，卷(期):2014年9卷20期

页码：1839-1843

DOI：10.4103/1673-5374.143432

附件：

收录: SCIE