Association between Phosphatase Related Gene Variants and Coronary Artery Disease: Case-Control Study and Meta-Analysis

作者

Han, X;Zhang, LJ;Zhang, ZQ;Zhang, ZT;Wang, JC;Yang, J;Niu, JM

作者单位

[Han, Xia; Zhang, Lijun; Zhang, Zhiqiang; Zhang, Zengtang; Niu, Jiamin] Laiwu Peoples Hosp, Dept Cardiol, Laiwu 271100, Peoples R China.;-;[Wang, Jianchun] Shandong Prov Hosp, Dept Cardiol, Jinan 250000, Peoples R China.;-;[Yang, Jun] Yantai Yuhuangding Hosp, Dept Cardiol, Yantai 264000, Peoples R China.

摘要

Recent studies showed that the serum alkaline phosphatase is an independent predictor of the coronary artery disease (CAD). In this work, we aimed to summarize the association between three phosphatase related single nucleotide polymorphisms (rs12526453, rs11066301 and rs3828329) and the risk of CAD in Han Chinese. Our results showed that the rs3828329 of the ACP1 gene was closely related to the risk of CAD in Han Chinese (OR = 1.45, p = 0.0006). This significant association of rs3828329 with CAD was only found in the females (Additive model: OR = 1.80, p = 0.001; dominant model: OR = 1.69, p = 0.03; recessive model: OR = 1.96, p = 0.0008). Moreover, rs3828329 was likely to exert its effect in females aged 65 years and older (OR = 2.27, p = 0.001). Further meta-analyses showed that the rs12526453 of PHACTR11 gene (OR = 1.14, p < 0.0001, random-effect method) and the rs11066301 of PTPN11 gene (OR = 1.15, p < 0.0001, fixed-effects method) were associated with CAD risk in multiple populations. Our results showed that the polymorphisms rs12526453 and rs11066301 are significantly associated with the CAD risk in multiple populations. The rs3828329 of ACP1 gene is also a risk factor of CAD in Han Chinese females aged 65 years and older.

关键词

PROTEIN-TYROSINE PHOSPHATASES; GENOME-WIDE ASSOCIATION; HEART-DISEASE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; CHINESE POPULATION; MUTATION ANALYSIS; NOONAN-SYNDROME; GASTRIC-CANCER; HAN CHINESE

基本信息

所属机构:

归属医师: 王建春

PMID：25123136

UT：000341519600056

刊名:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

年，卷(期):2014年15卷8期

页码：14058-14076

DOI：10.3390/ijms150814058

附件： pdf

收录: SCIE