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Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis

    作者

    Yu, LX;Zhou, NN;Liu, LY;Wang, F;Ma, ZB;Li, J;Yu, ZG

    作者单位

    [Yu, Li-Xiang; Wang, Fei; Ma, Zhong-Bing; Yu, Zhi-Gang] Shandong Univ, Hosp 2, Dept Breast Dis, Jinan 250100, Peoples R China.;-;[Zhou, Nan-Nan] Shandong Univ, Shandong Prov Hosp, Dept Aged Cardiovasc Dis, Jinan 250100, Peoples R China.;-;[Liu, Li-Yuan] Shandong Univ, Sch Publ Hlth, Inst Epidemiol, Jinan 250100, Peoples R China.;-;[Li, Jie] Shandong Univ, Sch Nursing, Inst Epidemiol, Jinan 250100, Peoples R China.

    摘要

    Many studies have indicated possible associations between a polymorphism of adiponectin receptor 1 (ADIPOR1) rs1342387 and risk of cancer, but contradictory results have been reported. The main aim of this study was to draw a reliable conclusion about the relationship between the rs1342387 polymorphism and cancer incidence, by conducting a literature search of Pubmed, Embase, Wanfang and Cochrane libraries. Eleven studies including 3, 738 cases and 4, 748 controls were identified in this meta-analysis. The ADIPOR1 rs1342387 polymorphism was associated with risk of colorectal cancer for all genetic comparison models (GG vs AA, OR: 1.44, 95% CI: 1.21 - 1.70; G carriers vs A carriers, OR: 1.23, 95% CI: 1.11 - 1.36; dominant model, OR: 1.28, 95% CI: 1.10 - 1.49 and recessive model, OR: 1.31, 95% CI: 1.12 - 1.55). Stratified by ethnicity, the rs1342387 polymorphism was significantly associated with risk of colorectal cancer in Asian ancestry for all genetic comparison models (GG vs AA, OR: 1.56, 95% CI: 1.26- 1.92; G carriers vs. A carriers OR: 1.30, 95% CI: 1.18 - 1.43; dominant model OR: 1.31, 95% CI: 1.08 - 1.60 and recessive model OR: 1.44, 95% CI: 1.26 - 1.64), but not in Caucasian or mixed (Caucasian mainly) groups. In summary, the ADIPOR1 rs1342387 polymorphism is significantly associated with risk of colorectal cancer among individuals of Asian ancestry.

    关键词

    COLORECTAL-CANCER; GENETIC-VARIATIONS; PROSTATE-CANCER; GASTRIC-CANCER; OBESITY; PATHWAY; ADIPOKINES; EXPRESSION; VARIANTS; BIAS
基本信息

  • 所属机构:

    归属医师: 周南南

    PMID：25292021

    UT：000343833600004

    刊名:ASIAN PACIFIC JOURNAL OF CANCER PREVENTION

    年，卷(期):2014年15卷18期

    页码：7515-7520

    DOI：10.7314/APJCP.2014.15.18.7515

    附件：

    收录:   SCIE