A longitudinal cohort based association study between uric acid level and metabolic syndrome in Chinese Han urban male population
作者
Zhang, Q;Zhang, CQ;Song, XH;Lin, HY;Zhang, DZ;Meng, WJ;Zhang, YY;Zhu, ZX;Tang, F;Liu, LJ;Yang, XW;Xue, FZ
作者单位
[Zhang, Qian; Meng, Wenjia; Zhang, Yongyuan; Zhu, Zhenxin; Xue, Fuzhong] Shandong Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Jinan 250012, Peoples R China.;-;[Zhang, Chengqi; Tang, Fang] Shandong Prov QianFoShan Hosp, Hlth Management Ctr, Jinan 250014, Peoples R China.;-;[Song, Xinhong; Lin, Haiyan; Zhang, Dongzhi] Shandong Univ, Prov Hosp, Ctr Hlth Management, Jinan 250012, Peoples R China.;-;[Liu, Longjian] Drexel Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA.;-;[Yang, Xiaowei] Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Davis, CA 95616 USA.
摘要
Background: It has been recently demonstrated that serum uric acid (UA) is associated with metabolic syndrome (MetS) or its related clinical indications based on cross-sectional or prospective cohort studies. Nonetheless, due to the fact that UA level constantly fluctuates from time to time even for the person, using a single measure of UA level at baseline of those studies may not be sufficient for estimating the UA-Mets association.;-;Methods: To further estimate this time-dependent association, we fitted a generalized estimating equation (GEE) regression model with data from a large-scale 6-year longitudinal study, which included 2222 participants aged > = 25 years with an average of 3.5 repeated measures of UA per person in the Health Management Center of Shandong Provincial Hospital, Shandong, China.;-;Results: After adjusting for other potential confounding factors (i. e., total cholesterol, low-density lipoprotein), it was verified that time-dependent UA level was an independent risk factor for MetS (OR = 1.6920, p < 0.0001). It was found that UA level was positively associated with obesity, hypertension, and dyslipidemia, but was inversely associated with hyperglycemia.;-;Conclusions: Serum UA level may serve as an important risk factor of MetS. Additionally, our study suggested that UA level be an independent risk factor to obesity, hypertension and dyslipidemia, but a protective factor to hyperglycemia. These findings are concordant with results from other studies on Asian populations, and jointly provide a basis to further develop a risk assessment model for predicting MetS using UA levels and other factors in China.
关键词
CARDIOVASCULAR-DISEASE; RISK-FACTORS; GENERAL-POPULATION; INNOCENT BYSTANDER; HYPERURICEMIA; INSULIN; GLUCOSE; ADULTS; MEN; HYPERTENSION
基本信息
