Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in humans and mice

作者

Xi, WJ;Hu, YJ;Liu, YG;Zhang, J;Wang, L;Lou, YW;Qu, ZH;Cui, J;Zhang, GZ;Liang, XH;Ma, CH;Gao, CJ;Chen, YH;Liu, SX

作者单位

[Xi, Wenjin; Hu, Yejia; Lou, Yunwei; Qu, Zhonghua; Cui, Jian; Zhang, Guizhong; Liang, Xiaohong; Ma, Chunhong; Gao, Chengjiang; Liu, Suxia] Shandong Univ, Sch Med, Inst Immunol, Jinan 250012, Peoples R China.;-;[Hu, Yejia] Binzhou Med Univ, Dept Pathophysiol, Binzhou, Peoples R China.;-;[Zhang, Jiao] Shandong Univ, Prov Hosp, Dept Hepatol, Jinan 250012, Peoples R China.;-;[Liu, Yugang] Shandong Univ, Sch Med, Dept Pathophysiol, Jinan 250012, Peoples R China.;-;[Wang, Lei] Shandong Univ, Hosp 2, Dept Infect Dis & Hepatol, Jinan 250012, Peoples R China.;-;[Chen, Youhai] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.;-;[Xi, Wenjin] Fourth Mil Med Univ, Dept Immunol, Xian, Peoples R China.

摘要

Hepatitis B virus (HBV)-induced hepatic inflammation afflicts hundreds of millions of people worldwide and is a leading cause of hepatic cancer. While the deleterious effect of the chronic hepatitis is well recognized, the molecular mechanisms underlying the pathogenesis of HBV-induced hepatic inflammation are not well understood. We report here that the tumor necrosis factor-alpha-induced protein-8 like-2 (TIPE2 or TNFAIP8L2), a newly identified regulator of immune receptor signaling, plays an important role in controlling HBV-induced hepatitis. Patients with chronic hepatitis B had significantly reduced levels of TIPE2 expression in their peripheral blood mononuclear cells (PBMCs) as compared to healthy individuals. The TIPE2 expression negatively correlated with the blood levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (Tbil) as well as the HBV load of the patients. Importantly, using a murine model of HBV-induced hepatitis, we found that TIPE2-deficient mice developed significantly more severe hepatic inflammation than wild type mice. These results indicate that TIPE2 plays an important role in taming HBV-induced hepatic inflammation. (C) 2011 Elsevier Ltd. All rights reserved.

关键词

CYTOTOXIC T-LYMPHOCYTES; IMMUNE HOMEOSTASIS; VIRAL-HEPATITIS; CELL-ACTIVATION; MESSENGER-RNA; IN-VIVO; LIVER; EXPRESSION; INFECTION; IMMUNOLOGY

基本信息

所属机构:

归属医师: 张娇

PMID：21466895

UT：000290929400014

刊名:MOLECULAR IMMUNOLOGY

年，卷(期):2011年48卷9-10期

页码：1203-1208

DOI：10.1016/j.molimm.2011.03.002

附件：

收录: SCIE