Secretion of antidiuretic hormone in children with obstructive sleep apnea-hypopnea syndrome
作者
Yue, ZY;Wang, MM;Xu, W;Li, H;Wang, HB
作者单位
[Yue, Zhiyong; Wang, Mingming; Xu, Wei; Li, Hong; Wang, Haibo] Shandong Univ, Prov Hosp, Dept Otorhinolaryngol, Jinan 250021, Peoples R China.
摘要
Conclusions: Obstructive sleep apnea-hypopnea syndrome (OSAHS) in children with hypoxemia might influence the nocturnal secretion of antidiuretic hormone (ADH) that is associated with polyuria, even nocturia. Objective: The impact of OSAHS on the secretion levels of ADH was studied in pediatric patients with adenotonsillar hypertrophy. Subjects and methods: Forty-eight children (28 with OSAHS, 20 as normal controls) were recruited in this study. Respiratory indexes of all subjects were monitored by polysomnography and 12-h urinary volume was recorded during sleep. Vein blood was sampled to detect the levels of ADH in serum using a radioimmunoassay technique, both before and after adenotonsillectomy. Results: After surgery for OSAHS, the mean value of the apnea-hypopnea index (AHI) decreased (from 17.36 +/- 2.61 to 3.32 +/- 1.41, p<0.001), lowest arterial oxygen saturation (LSaO(2)) increased (from 78.34 +/- 13.44 to 95.35 +/- 6.24, p<0.001), urine volume (UV) in nocturnal 12 h reduced (from 492 +/- 90 to 332 +/- 56, p<0.001), and ADH level increased (from 63.08 +/- 35.15 to 83.10 +/- 21.05, p<0.05). The differences in UV and ADH between postoperative children and healthy controls were not statistically significant (both p>0.05).
关键词
BLOOD-PRESSURE
基本信息
