SPECT study of Chinese schizophrenic patients suggests that cerebral hypoperfusion and laterality exist in different ethnic groups

作者

Li, XB;Tang, JS;Wu, ZX;Zhao, GF;Liu, CY;George, MS

作者单位

Med Univ S Carolina, Inst Psychiat, Brain Stimulat Lab, Charleston, SC 29425 USA.;-;Med Univ S Carolina, Ctr Adv Imaging Res, Charleston, SC 29425 USA.;-;Shandong Univ, Dept Psychiat, Jinan 250100, Shandong, Peoples R China.;-;Shandong Prov Mental Hlth Ctr, Jinan, Shandong, Peoples R China.;-;Shandong Prov Hosp, Dept Radiol, Jinan, Shandong, Peoples R China.

摘要

Hypofrontality is a common finding in schizophrenia in many countries. To date, there have been few studies on Chinese patients with schizophrenia. We thus wondered whether hypofrontality exists in Chinese patients with schizophrenia. We investigated 45 patients with schizophrenia and 21 healthy controls using brain perfusion single photon emission computed tomography (SPECT). Subjects were also administered the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Positive Symptoms (SAPS), Scale for the Assessment of Negative Symptoms (SANS), Halstead-Reitan Neuropsychological Battery (HRNB) and the Wechsler Memory Scale-Revised (WMS-R). Images were analyzed using a semi-quantitative reading and a quantified region of interest analysis. We found that schizophrenic patients showed hypoperfusion in the frontal and temporal lobes and hyperperfusion in the basal ganglia. Schizophrenic patients with both negative and positive symptoms showed asymmetric perfusion in the temporal lobe. Schizophrenic patients with prominent negative symptoms also showed asymmetric perfusion in the prefrontal lobes. Negative symptoms showed a significantly negative correlation with regional cerebral blood flow (rCBF) in the left frontal lobe. Improved memory quotient (MQ) was significantly correlated with increased rCBF in the left temporal lobe. These findings from Chinese patients confirm a similar regional neuroanatomic dysfunction as in Western patients with the disease.

关键词

EMISSION-COMPUTED-TOMOGRAPHY; TC-99M HMPAO-SPECT; BLOOD-FLOW; NEGATIVE SYMPTOMS; METABOLIC-ACTIVITY; MEMORY; HYPOFRONTALITY; DYSFUNCTION; DEFICIT; MRI

基本信息

所属机构:

归属医师: 吴志兴

PMID：16156482

UT：000230242300004

刊名:WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

年，卷(期):2005年6卷2期

页码：98-106

DOI：10.1080/15622970510029821

附件：

收录: SCIE