Prognostic value of coronary atherosclerosis progression evaluated by coronary CT angiography in patients with stable angina
作者
Gu, H; Gao, Y; Hou, ZH; Schoepf, UJ; Snyder, AN; Duguay, TM; Wang, XM; Lu, B
作者单位
[Gu, Hui; Wang, Ximing] Shandong Univ, Shandong Med Imaging Res Inst, Shandong Prov Key Lab Diag & Treatment CardioCere, Dept CT, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China; [Gu, Hui; Gao, Yang; Hou, Zhihui; Lu, Bin] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Dept Radiol,Fuwai Hosp, 167 Bei Li Shi St, Beijing 100037, Peoples R China; [Gu, Hui; Gao, Yang; Hou, Zhihui; Lu, Bin] Peking Union Med Coll, 167 Bei Li Shi St, Beijing 100037, Peoples R China; [Schoepf, U. Joseph; Snyder, Alan N.; Duguay, Taylor M.] Med Univ South Carolina, Div Cardiovasc Imaging, Dept Radiol & Radiol Sci, 25 Courtenay Dr, Charleston, SC 29403 USA
摘要
To investigate the progression of coronary atherosclerosis burden by coronary CT angiography (CCTA) and to demonstrate its association with the incidence of major adverse cardiac events (MACE). We retrospectively studied patients with stable angina who had undergone repeat CCTA due to recurrent or worsening symptoms. Lipid-rich, fibrous, calcified and total plaque burden as well as coronary diameter stenosis were quantitatively analysed. The incidence of MACE during follow-up was determined. The final cohort consisted of 268 patients (mean age 52.9 +/- 9.8 years, 71 % male) with a mean follow-up period of 4.6 +/- 0.9 years. Patients with lipid-rich, fibrous, calcified and total plaque burden (%) progression, as well as coronary diameter stenosis (%) progression had a significantly higher incidence of MACE than those without (all p < 0.05). The progression of lipid-rich plaque (HR = 1.601, p = 0.021), total plaque burden (HR = 2.979, p = 0.043) and coronary diameter stenosis (HR = 4.327, p < 0.001) were independent predictors of MACE (all p < 0.05). Patients presenting with recurrent or worsening symptoms associated with coronary artery disease who have coronary atherosclerosis progression on CCTA are at an increased risk of future MACE. aEuro cent Repeat CCTA can provide information regarding the progression of coronary atherosclerosis. aEuro cent Coronary atherosclerosis progression at CCTA is independently associated with MACE. aEuro cent CCTA findings could serve as incremental predictors of MACE.
关键词
MULTIDETECTOR COMPUTED-TOMOGRAPHY; ARTERY CALCIUM; INTRAVASCULAR ULTRASOUND; PLAQUE CHARACTERIZATION; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; AMERICAN-COLLEGE; NATURAL-HISTORY; RISK; ASSOCIATION
基本信息
