Effects of Titanium Nano-Foveolae Surfaces on Human Gingival Fibroblasts

作者

Zhang, YJ; Zhang, YL; Kong, TT; Ye, B; Li, XY; Ji, P; Sun, SJ

作者单位

[Zhang, Yujun; Li, Xiaoyan; Ji, Ping; Sun, Shengjun] Shandong Univ, Shandong Prov Key Lab Oral Biomed, Coll Stomatol, Jinan 250014, Shandong, Peoples R China; [Zhang, Yilin] Shandong Univ, Shandong Prov Hosp, Dept Stomatol, Jinan 250014, Shandong, Peoples R China; [Kong, Tingting] Xi An Jiao Tong Univ, Key Lab Shanxi Prov Craniolacial Precis Med Res, Coll Stomatol, Xian 710000, Shaanxi, Peoples R China; [Kong, Tingting] Xi An Jiao Tong Univ, Clin Res Ctr Shanxi Prov Dent & Maxillofacial Dis, Coll Stomatol, Xian 710000, Shaanxi, Peoples R China; [Ye, Bin] Sichuan Univ, State Key Lab Oral Dis, West China Sch Stomatol, Chengdu 610000, Sichuan, Peoples R China

摘要

A proper soft tissue seal between implants and gingiva is critical for success of dental implants. Implant surface modification is an important approach for achieving ideal host-implant integration. In this study, we used a new and simple oxidation method to generate a rough surface on implants at the nano scale, which oxidized titanium nano-foveolae (TiNF) surface. We further analyzed the surface topography and tested its effects on biological activities of human gingival fibroblasts. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) examination demonstrated that TiNF disks displayed uniform rough surfaces, with average TiNF diameters of approximately 60 nm and 100 nm respectively. However the surfaces of smooth samples were highly irregular, and cell adhesion and proliferation rates on TiNF surfaces were significantly higher than those of the smooth surfaces. Extracellular matrix synthesis was also increased in the cells that interacted with oxidized TiNF surfaces. Altogether, these results suggest that the TiNF implant surfaces perform better for human gingival fibroblast biological activities compared to traditional smooth surfaces. Therefore, the TiNF implant surfaces may serve as ideal interface to facilitate implant-host integration.

关键词

GENE-EXPRESSION; TOPOGRAPHY; IMPLANTS; FABRICATION; INTEGRATION; MORPHOLOGY; ADHESION

基本信息

所属机构:

归属医师: 张益琳

PMID：31383062

UT：000484777500003

刊名:JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

年，卷(期):2020年20卷2期

页码：673-679

DOI：10.1166/jnn.2020.16917

附件： other

收录: SCIE