Fenofibrate-induced hepatotoxicity: A case with a special feature that is different from those in the LiverTox database

作者

Ma, SZ; Liu, SD; Wang, Q; Chen, LJ; Yang, P; Sun, HH

作者单位

[Ma, Shizhan] Shandong First Med Univ, Shandong Prov Hosp, Dept Endocrinol & Metab, Jinan, Shandong, Peoples R China; [Liu, Shudong; Chen, Lijuan; Yang, Ping; Sun, Huihuan] Shandong Rongjun Gen Hosp, Dept Endocrinol, 23 Jiefang Rd, Jinan 250013, Shandong, Peoples R China; [Wang, Qi] Fifth Peoples Hosp Jinan, Dept Pharm, Jinan, Shandong, Peoples R China

摘要

What is known and objective We report a special case of fenofibrate-induced acute severe DILI with sudden onset and rapid recovery, which is different from those in the LiverTox database. Case summary description The acute severe DILI occurred within only 4 days after fenofibrate initial treatment for hypertriglyceridemia. Liver enzyme levels eventually declined to normal within two weeks after the discontinuation of fenofibrate. What is new and Conclusion Early detection of elevated hepatic enzymes after fenofibrate initial treatment helps physicians to avoid delayed diagnosis and subsequent treatment.

关键词

TRANSAMINASE GENE-EXPRESSION; CARDIOVASCULAR-DISEASE; INJURY; INTERVENTION; HEPATITIS; DYSLIPIDEMIA; POPULATION; FAILURE

基本信息

所属机构:内分泌

归属医师: 马世瞻

PMID：31518450

UT：000486453800001

刊名:JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

年，卷(期):2020年45卷1期

页码：204-207

DOI：10.1111/jcpt.13042

附件： other

收录: SCIE