Pooled analysis of the efficacy and safety of intraoperative dexmedetomidine on postoperative catheter-related bladder discomfort

作者

Shi, HB; Zhang, HP; Pan, WZ; Lu, YY; Zhang, Y; Chen, LJ; Wei, CX; Cui, YS

作者单位

[Shi, Hongbin] Ningxia Med Univ, Dept Urol, Gen Hosp, Yinchuan, Ningxia, Peoples R China; [Zhang, Huaping] Qingdao Univ, Dept Gastrointestinal Surg Ward 2, Affiliated Yantai Yuhuangding Hosp, Yantai, Peoples R China; [Pan, Weizhong] Qingdao Univ, Dept Anesthesiol, Affiliated Yantai Yuhuangding Hosp, Yantai, Peoples R China; [Lu, Youyi; Cui, Yuanshan] Qingdao Univ, Dept Urol, Affiliated Yantai Yuhuangding Hosp, 119 South 4th Ring West Rd, Yantai 100070, Peoples R China; [Zhang, Yong; Cui, Yuanshan] Capital Med Univ, Beijing Tian Tan Hosp, Dept Urol, Beijing, Peoples R China; [Chen, Linjing] Qingdao Univ, Affiliated Yantai Yuhuangding Hosp, Dept Operating Room, Yantai, Peoples R China; [Wei, Chunxiao] Shandong First Med Univ, Shandong Prov Hosp, Dept Urol, Jinan, Peoples R China

摘要

Objectives The goal of the pooled analysis was to demonstrate the efficacy and safety of intraoperative dexmedetomidine in postoperative catheter-related bladder discomfort (CRBD). Methods MEDLINE, the Cochrane Central Register of Controlled Trials, and the Excerpta Medica Database (Embase) were used to pick out randomized controlled trials (RCTs) that used intraoperative dexmedetomidine in postoperative CRBD. This study was carried out using the preferred reporting items for systematic reviews and pooled analysis. We used RevMan version 5.3.0. to analyze the data. Results Seven RCTs involving 607 patients were brought into in the analysis. The incidence of CRBD and the incidence of moderate to severe CRBD were assessed at 0 hours, 0.5 or 1 hour, 2 or 3 hours, 6 hours, and 12 or 24 hours postoperatively. The analysis proved that both the incidence of CRBD (P < .00001) and the incidence of moderate to severe CRBD had a statistically significant reduction at 0 hours, 0.5 or 1 hours, 2 or 3 hours, and 6 hours postoperatively (P < .00001, P <.00001, P <.00001, P = .003, respectively). The postoperative pain score was lower in the dexmedetomidine group at 0 hours (P < .00001) and 1 hour (P = .002). Safety assessments indicated that there were no statistical differences between dexmedetomidine and control for side effects, mainly including dry mouth (P = .99) and postoperative vomiting and nausea (P = .77). Conclusions The pooled analysis demonstrates that intraoperative dexmedetomidine administration decreases the rate and severity of early postoperative CRBD without causing significant side effects.

关键词

DOUBLE-BLIND; URINARY-TRACT; PREVENTION; ANTAGONISTS; RESECTION; INFUSION

基本信息

所属机构:

归属医师: 尉春晓

PMID：32495997

UT：000537540000001

刊名:LUTS-LOWER URINARY TRACT SYMPTOMS

年，卷(期):2021年13卷1期

页码：38-44

DOI：10.1111/luts.12322

附件： other

收录: SCIE