Neuroprotective effect of rhaponticin against Parkinson disease: Insights from in vitro BV-2 model and in vivo MPTP-induced mice model

作者

Zhao, FF; Tian, HJ; Chinnathambi, A; Alharbi, SA; Yang, HG

作者单位

[Zhao, Fangfang] Henan Univ, Huaihe Hosp, Dept Neurol, Kaifeng City, Henan, Peoples R China; [Tian, Huijun] Beijing Beiya Orthoped Hosp, Dept Neurosurg, Beijing, Peoples R China; [Chinnathambi, Arunachalam; Alharbi, Sulaiman Ali] King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh, Saudi Arabia; [Yang, Hongan] Shandong First Med Univ, Dept Neurosurg, Shandong Prov Hosp, 324 Jingwuweiqi Rd, Jinan 250021, Shandong, Peoples R China

摘要

Parkinson's disease (PD) is a complex neurodegenerative illness associated with the loss or damage to neurons of the dopaminergic system in the brain. Few therapeutic approaches and considerable side effects of conventional drugs necessitate a new therapeutic agent to treat patients with PD. Rhaponticin is a natural hydroxystilbene, found in herbal plants such asRheum rhaponticum, and known to have desirable biological activity including anti-inflammatory properties. However, the neuroinflammation on rhaponticin levels has only been investigated partially so far. So, the current study explored whether rhaponticin could ameliorate the pathophysiology observed in both the in vitro microglial BV-2 cells and the in vivo (1-methyl-4-phenyl-1,2,3,5-tetrahydropyridine [MPTP])-mediated PD model. The results show rhaponticin significantly attenuated lipopolysaccharide (LPS)-mediated microglial activation by suppressing nitric oxide synthase in conjunction with abridged reactive oxygen species production together with proinflammatory mediator reduction. In vivo rhaponticin treatment improves motor impairments as well as the loss of dopaminergic neurons in MPTP-treated mice possibly through suppression via mediators of inflammation. Taken together, these results offer evidence that rhaponticin exerts anti-inflammatory effects and neuroprotection in an LPS-induced microglial model and the MPTP-induced mouse models of PD.

关键词

INFLAMMATORY RESPONSES; NEUROINFLAMMATION; NEURODEGENERATION; PROTECTS

基本信息

所属机构:

归属医师: 杨洪安

PMID：32926752

UT：000569361200001

刊名:JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

年，卷(期):2021年35卷1期

DOI：10.1002/jbt.22631

附件： other

收录: SCIE