Role of Gut Microbiome and Microbial Metabolites in Alleviating Insulin Resistance After Bariatric Surgery
作者
Wang, MF; Li, LP; Chen, YZ; Lian, GD; Wang, JS; Zhang, JZ; Shan, KS; Shang, L; Tian, F; Jing, CQ
作者单位
[Wang, Mingfei; Li, Leping; Chen, Yuezhi; Lian, Guodong; Wang, Jinshen; Zhang, Jizhun; Shan, Keshu; Shang, Liang; Tian, Feng; Jing, Changqing] Shandong Univ, Shandong Prov Hosp, Dept Gastrointestinal Surg, Cheeloo Coll Med, Jinan 250021, Peoples R China; [Li, Leping; Chen, Yuezhi; Lian, Guodong; Wang, Jinshen; Zhang, Jizhun; Shan, Keshu; Shang, Liang; Tian, Feng; Jing, Changqing] Shandong First Med Univ, Dept Gastrointestinal Surg, Shandong Prov Hosp, Jinan 250021, Peoples R China
摘要
Insulin resistance (IR) is the most common pathophysiological change in patients with type 2 diabetes mellitus (T2DM). Several recent studies have suggested that the gut microbiome and microbial metabolites are involved in the pathogenesis of IR. Bariatric surgery, as an effective treatment for T2DM, can markedly alleviate IR through mechanisms that have not been elucidated. In this review, we summarize the current evidence on the changes in the gut microbiome and microbial metabolites (including lipopolysaccharide, short-chain fatty acids, branched-chain amino acids, aromatic amino acids, bile acids, methylamines, and indole derivatives) after bariatric surgery. Additionally, we discuss the mechanisms that correlate the changes in microbial metabolites with the postoperative alleviation of IR. Furthermore, we discuss the prospect of bariatric surgery as a treatment for T2DM.
关键词
Y GASTRIC BYPASS; CHAIN FATTY-ACIDS; BILE-ACIDS; INTESTINAL MICROBIOTA; RECEPTOR SUBSTRATE-1; GLUCOSE-TOLERANCE; SERUM METABOLOME; BRANCHED-CHAIN; S-NITROSATION; AMINO-ACIDS
基本信息
