Correlation between abnormal N-acetyl-aspartate levels in posterior cingulate cortex and persistent auditory verbal hallucinations in Chinese patients with chronic schizophrenia

作者

Ren, HH; Wang, QJ; Li, CW; Li, JG; Dai, LL; Dong, M; Zhou, J; He, JQ; Liao, YH; He, Y; Li, ZC; Chen, XG; Tang, JS

作者单位

[Ren, Honghong; Wang, Qianjin; Li, Jinguang; Dai, Lulin; Zhou, Jun; He, Jingqi; He, Ying; Li, Zongchang; Chen, Xiaogang] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China; [Ren, Honghong; Wang, Qianjin; Li, Jinguang; Dai, Lulin; Zhou, Jun; He, Jingqi; He, Ying; Li, Zongchang; Chen, Xiaogang] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China; [Ren, Honghong] Shandong First Med Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R China; [Li, Chunwang] Hunan Childrens Hosp, Dept Radiol, Changsha, Hunan, Peoples R China; [Dong, Min] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Guangdong, Peoples R China; [Liao, Yanhui; Tang, Jinsong] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Psychiat, Hangzhou, Zhejiang, Peoples R China; [Li, Zongchang; Chen, Xiaogang] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China; [Tang, Jinsong] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Psychiat, Hangzhou 310016, Zhejiang, Peoples R China

摘要

The aim of this study was to investigate the relationship between persistent auditory verbal hallucinations (pAVHs) and N-acetyl-aspartate (NAA) levels in posterior cingulate cortex (PCC). 117 schizophrenia (SCZ) pa-tients (61 pAVHs and 56 non-AVHs) and 66 healthy controls were included. The P3 item of the Positive and Negative Syndrome Scale and the Auditory Hallucinations subscale of the Psychotic Symptom Rating Scale were used to assess the severity of pAVHs. NAA levels were significantly lower in the AVHs group, and were negatively correlated with pAVHs. Therefore, increasing the NAA levels in PCC may be helpful in treating pAVHs.

关键词

基本信息

所属机构:心理科门诊

归属医师: 任红红

PMID：36577325

UT：000911214300001

刊名:ASIAN JOURNAL OF PSYCHIATRY

年，卷(期):2023年80卷期

页码：-null

DOI：10.1016/j.ajp.2022.103416

附件： other

收录: SCIE