Fusobacterium nucleatum: a new player in regulation of cancer development and therapeutic response
作者
Zhao, TD; Wang, XP; Fu, LW; Yang, K
作者单位
[Zhao, Tengda; Yang, Ke] Shandong First Med Univ, Shandong Prov Hosp, Dept Hlth Management Ctr, Dept Oral & Maxillofacial Surg, 324 Weiqi Rd, Jinan 250021, Shandong, Peoples R China; [Wang, Xueping; Fu, Liwu] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol Southern China, 651 Dongfeng East Rd, Guangzhou 510060, Guangdong, Peoples R China
摘要
A dysbiosis in microbial diversity or functionality can promote disease development. Emerging preclinical and clinical evidence emphasizes the interplay between microbiota and both disease evolution and the treatment response of different cancers. One bacterium that has garnered much attention in a few cancer microbiota studies is Fusobacterium nucleaum (Fn). To provide updated knowledge of the functional role of Fn in cancer prevention and management, this review summarizes the relationship among Fn, cancer, and chemoimmunotherapy response, with the potential mechanisms of action also intensively discussed, which will benefit the development of strategies to prevent or treat cancer via Fn-based therapeutic interventions.
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基本信息
