Branched-Chain Amino Acids Metabolism and Their Roles in Retinopathy: From Relevance to Mechanism

作者

Zhang, XA; Xia, MX; Wu, YJ; Zhang, F

作者单位

[Zhang, Xiaonan; Xia, Mengxue; Zhang, Fang] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Natl Clin Res Ctr Eye Dis, Shanghai 200080, Peoples R China; [Zhang, Xiaonan; Wu, Yingjie] Dalian Med Univ, Inst Genome Engn Anim Models Human Dis, Natl Ctr Genet Engn Anim Models Int Res, Liaoning Provence Key Lab Genome Engn Anim Models, Dalian 116000, Peoples R China; [Zhang, Xiaonan; Xia, Mengxue; Zhang, Fang] Shanghai Key Lab Ocular Fundus Dis, Shanghai 200080, Peoples R China; [Wu, Yingjie] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Prov Hosp, Sch Lab Anim, Jinan 250021, Peoples R China; [Wu, Yingjie] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Lab Anim Ctr, Sci & Technol Innovat Ctr, Jinan 250021, Peoples R China; [Wu, Yingjie] New York Univ Coll Dent, Dept Mol Pathobiol, New York, NY 10010 USA

摘要

Retinopathy is one of the leading causes of irreversible blindness and vision loss worldwide. Imbalanced nutrients play important roles in the pathogenesis and pathophysiology of retinal diseases. Branched-Chain Amino Acids (BCAAs), as essential amino acids, perform a variety of biological functions, including protein synthesis, glucose metabolism, lipid metabolism, inflammation, and oxidative stress in metabolic tissues of diabetes and aging-related diseases. Recently, it has been shown that BCAAs are highly related to neuroprotection, oxidative stress, inflammatory and glutamate toxicity in the retina of retinopathy. Therefore, this review summarizes the alterations of BCAA levels in retinopathy, especially diabetic retinopathy and aging-related macular disease, and the genetics, functions, and mechanisms of BCAAs in the retina as well as other metabolic tissues for reference. All of these efforts aim to provide fundamental knowledge of BCAAs for further discoveries and research on retina health based on the sensing and signaling of essential amino acids.

关键词

基本信息

所属机构:

归属医师: 吴英杰

PMID：37432261

UT：000987024200001

刊名:NUTRIENTS

年，卷(期):2023年15卷9期

页码：-null

DOI：10.3390/nu15092161

附件： other other

收录: SCIE