Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases
作者
Lin, YN; Ran, LY; Du, XM; Yang, HY; Wu, YJ
作者单位
[Lin, Yani; Ran, Liyuan; Wu, Yingjie] Shandong First Med Univ, Shandong Prov Hosp, Sch Lab Anim, Jinan 250021, Shandong, Peoples R China; [Lin, Yani; Ran, Liyuan; Wu, Yingjie] Shandong First Med Univ, Shandong Lab, Anim Ctr, Sci & Technol Innovat Ctr, Jinan 250021, Shandong, Peoples R China; [Lin, Yani; Ran, Liyuan; Wu, Yingjie] Shandong Acad Med Sci, Jinan 250021, Shandong, Peoples R China; [Ran, Liyuan; Wu, Yingjie] Dalian Med Univ, Inst Genome Engn Anim Models Human Dis, Natl Ctr Genet Engn Anim Models Int Res, Dalian 116044, Liaoning, Peoples R China; [Du, Ximing; Yang, Hongyuan] Univ New South Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia; [Wu, Yingjie] NYU, Coll Dent, Dept Mol Pathobiol, New York, NY 10010 USA
摘要
Oxysterol-binding protein (OSBP) mediates lipid exchange between organelles at membrane contact sites, thereby regulating lipid dynamics and homeostasis. How OSBP's lipid transfer function impacts health and disease remain to be elucidated. In this review, we first summarize the structural characteristics and lipid transport functions of OSBP, and then focus on recent progresses linking OSBP with fatty liver disease, diabetes, lysosome-related diseases, cancer and viral infections, with the aim of discovering novel therapeutic strategies for common human diseases.
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