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TPH2 Gene Polymorphisms and Major Depression - A Meta-Analysis
Gao, J;Pan, ZL;Jiao, ZA;Li, F;Zhao, GQ;Wei, QQ;Pan, F;Evangelou, E
PLOS ONE 2012年 7卷5期 影响因子:3.057
TRYPTOPHAN HYDROXYLASE-2 GENE; OF-FUNCTION MUTATION; HAPLOTYPE ANALYSIS; CANDIDATE GENES; MOOD DISORDERS; NO ASSOCIATION; UNIPOLAR; POPULATION; EPIDEMIOLOGY; RELATIVES
Background: Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (CNS). Gene-disease association studies have reported a relationship between TPH2 and major depressive disorder (MDD) in different populations, however subsequent studies have produced contradictory results.;-;Objectives: We performed a systematic overview and a meta-analysis with all available data up-to-date.;-;Methods: We scrutinized PubMed, Embase, HuGNet and China National Knowledge Infrastructure (CNKI) and last update was held on October 2011. We also searched the manuscripts and the supplementary documents of the published genome-wide association studies in the field. Effect sizes of independent loci that have been studied in more than 3 articles were synthesized using fixed and random effects models.;-;Results: We found 27 eligible articles that studied a total of 74 single nucleotide polymorphisms (SNPs). Finally, 12 independent loci were included in the meta-analysis. The synthesis of the data shown that two SNPs (rs4570625 and rs17110747) were associated with MDD using fixed effects models. SNP rs4570625 had low heterogeneity and remained significant using the more conservative random effects calculations with a summary OR = 0.83 (95% CI: 0.73-0.96).;-;Conclusion: The current study identified a SNP (rs4570625) with strong epidemiological credibility; however more studies are required to provide robust evidence for other weak associations.
女性类风湿关节炎患者述情障碍与心理健康状况研究
高进;潘正论;赵国庆;李芹;焦志安;张敬悬
中华风湿病学杂志 2014年 18卷10期 页码:686-691页,共6页 影响因子:0.753
关节炎, 类风湿;心理健康;述情障碍
目的:探讨女性 RA 患者述情障碍与其心理健康状况之间的关系。方法采用多伦多述情障碍量表(TAS)-20、症状自评量表(SCL)-90分别对54例女性 RA 患者进行测查,记录并评估患者病程和 DAS28等临床资料,以50名健康女性作为对照,RA 组与对照组以及区组间数据比较采用 t 检验,患者述情障碍、SCL-90与病程及 DAS28之间的相关性采用 Spearman 相关分析。结果①女性 RA 患者TAS-20总分(57±9)高于健康对照组(51±7)(t=4.15,P<0.01),各因子分也高于健康对照组(P 均<0.01);SCL-90总分(165±50)高于健康对照组(138±41)(t=3.06,P<0.05),其余各因子分(偏执因子除外)也均高于健康对照组(P 均<0.01));② Tf1因子与 SCL-90的各项因子均呈正相关(P<0.05),Tf3因子与强迫、人际敏感、恐怖、偏执因子呈正相关(P<0.05),TAS-20总分与各因子均分呈正相关(躯体化因子除外)(P<0.05);③TAS-20高/低分组间 SCL-90结果比较:Tf1因子2组间强迫、焦虑和恐怖因子差异有统计学意义(P<0.05),Tf3因子在强迫、人际敏感、抑郁、敌对、偏执、精神病性因子上差异有统计学意义(P<0.05);SCL-90总分高/低分组间 TAS-20结果比较:Tf1因子2组间差异有统计学意义(P<0.01);④病程与 SCL-90的抑郁和偏执因子呈正相关(P 均<0.01), DAS28与 SCL-90的焦虑和偏执因子呈正相关(P<0.05)。结论女性 RA 患者存在较明显的述情障碍及多种心理问题,心理健康状况较差,且 TAS-20的 Tf1、Tf3因子、病程及疾病活动度都与其心理健康状况明显相关。
Correlation between abnormal N-acetyl-aspartate levels in posterior cingulate cortex and persistent auditory verbal hallucinations in Chinese patients with chronic schizophrenia
Ren, HH; Wang, QJ; Li, CW; Li, JG; Dai, LL; Dong, M; Zhou, J; He, JQ; Liao, YH; He, Y; Li, ZC; Chen, XG; Tang, JS
ASIAN JOURNAL OF PSYCHIATRY 2023年 80卷 页码:-null
无关键词信息
The aim of this study was to investigate the relationship between persistent auditory verbal hallucinations (pAVHs) and N-acetyl-aspartate (NAA) levels in posterior cingulate cortex (PCC). 117 schizophrenia (SCZ) pa-tients (61 pAVHs and 56 non-AVHs) and 66 healthy controls were included. The P3 item of the Positive and Negative Syndrome Scale and the Auditory Hallucinations subscale of the Psychotic Symptom Rating Scale were used to assess the severity of pAVHs. NAA levels were significantly lower in the AVHs group, and were negatively correlated with pAVHs. Therefore, increasing the NAA levels in PCC may be helpful in treating pAVHs.
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