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Tip60: Main Functions and Its Inhibitors
Zhang, XL;Wu, JY;Luan, YP
MINI-REVIEWS IN MEDICINAL CHEMISTRY 2017年 17卷8期 页码:675-682
DOUBLE-STRAND BREAKS; HISTONE ACETYLTRANSFERASE ACTIVITY; ANDROGEN RECEPTOR COACTIVATORS; TELANGIECTASIA MUTATED KINASE; DEPENDENT PROTEIN-KINASE; ACETYL TRANSFERASE TIP60; DNA-DAMAGE; PROSTATE-CANCER; LYSINE ACETYLTRANSFERASES; IONIZING-RADIATION
Background: Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates.;-;Results: Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers.;-;Conclusion: Here, main functions and its known inhibitors were summarized.
The complete chloroplast genome sequence of Fatsia japonica (Apiales: Araliaceae) and the phylogenetic analysis
Chen, QY;Feng, X;Li, MZ;Yang, BX;Gao, CX;Zhang, L;Tian, JK
MITOCHONDRIAL DNA PART A 2016年 27卷4期 页码:3050-3051
ANNOTATION
In this study, we have sequenced the complete chloroplast genome of Fatsia japonica, a well-known ornamental and potential medicinal plant. The complete chloroplast genome of F. japonica is 155 613 bp in length with 62.09% AT content, has a typical quadripartite structure with large (LSC 86 487 bp) and small (SSC 17 866 bp) single-copy regions separated by a pair of inverted repeats (IRs 25 929 bp) and contains 114 unique genes with 18 genes duplicated in the IR making a total of 132 genes. The phylogenetic analysis indicated the position of F. japonica in Apiales and has the potential to facilitate a better understanding of the intergeneric relationships in the family.
Multi-Component HPLC Analysis and Antioxidant Activity Characterization of Extracts from Dipsacus sativus (Linn.) Honck
Yang, BX;Feng, X;Xu, JK;Lei, HX;Zhang, L
INTERNATIONAL JOURNAL OF FOOD PROPERTIES 2016年 19卷5期 页码:1000-1006
PERFORMANCE LIQUID-CHROMATOGRAPHY; TRADITIONAL CHINESE MEDICINE; CHEMICAL-ANALYSIS; QUALITY-CONTROL; ARRAY DETECTOR; FLAVONOIDS; LEAVES; SPECTROMETRY; RISK
A highly reliable high-performance liquid chromatography method was developed and validated for determining quality of extracts from the leaves of Dipsacus sativus (Linn.) Honck. Under optimum conditions, the chromatography profile of eight compounds was collected, with compound saponarin as marker. The analysis results indicated that saponarin and isovitexin were the main active components. Pharmacological experiments proved that extracts from the leaves showed significant antioxidant activity. This work could serve to validate the usefulness of high-performance liquid chromatography analyses in traditional Chinese medicine.
Establishment of rat pneumococcal meningitis models: a histopathological analysis
Liu, XJ;Zhang, XL;Han, QZ
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 2015年 8卷2期 页码:2242-2248
CEREBRAL-BLOOD-FLOW; BACTERIAL-MENINGITIS; NEONATAL MENINGITIS; EPIDEMIOLOGY; SURVEILLANCE
The aim of this study was to perform a preliminary investigation of the pathogenesis of bacterial meningitis-induced brain injury by establishing rat pneumococcal meningitis models. Infant Wistar rats were intracranially inoculated with different concentrations of Streptococcus pneumoniae. Rats were sacrificed at different time points to observe clinical symptoms and pathological changes in brain tissues. Twenty-four hours after intracranial inoculation with Streptococcus pneumoniae, regardless of high or low concentrations of bacterial inoculation, all rats developed bacterial meningitis with manifestations such as lethargy and seizures. Pathological changes in brain tissues included subarachnoid and intraventricular inflammation, vasodilation and vascular congestion, and cortical neuronal necrosis. The number of rats with seizures, the degree of cerebral vascular disease, and the extent of neuronal damage were associated with the concentration of bacterial inoculum. Thirty days after infection, brain tissue weight significantly reduced. The pathological changes induced by inoculation with pneumococcal meningitis in Wistar rats were similar to those seen in the human brain. The possible mechanisms of brain damage caused by meningitis are cerebrovascular inflammation and disruption of regional cerebral blood flow.
Current development in nanoformulations of docetaxel
Tan, Q;Liu, XJ;Fu, XY;Li, QL;Dou, JF;Zhai, GX
EXPERT OPINION ON DRUG DELIVERY 2012年 9卷8期 页码:975-990
SOLID LIPID NANOPARTICLES; PHASE-II TRIAL; TARGETED DRUG-DELIVERY; BLOOD-BRAIN-BARRIER; IN-VIVO EVALUATION; TISSUE DISTRIBUTION; CHITOSAN NANOPARTICLES; CANCER-CHEMOTHERAPY; COPOLYMER MICELLES; OVARIAN-CANCER
Introduction: Docetaxel (DTX) has been proven as one of the most important cytotoxic agents, and its clinical efcacy against many cancers is superior to paclitaxel. DTX in commercial formulation contains the non-ionic surfactant Tween 80 (polysorbate 80) and 13% ethanol; the side effects caused by DTX and the solvent have considerably limited its clinical use. In recent decades, the emergence of nanoformulations provides new modes of actions in DTX. Many nano-sized carriers can help DTX transport through leaky tumor capillary fenestrations into the tumor cells. Moreover, these particles can be modified for binding to specific sites such as cancer cell membranes, cytoplasmic or nuclear receptors.;-;Areas covered: The authors focus on nanoformulations related to DTX delivery, covering their preparation, physicochemical properties and the in vitro and in vivo actions against tumor cells. The challenges involved in the development of nanoformulations for DTX are also discussed.;-;Expert opinion: Although nanoformulations such as liposome, micelle, nanoparticle, nanoemulsion greatly improve the solubility, activity and distribution of DTX in vivo, significant hurdles remain concerning aspects of nanoformulations such as quality control, physicochemical stability, storage conditions, large-scale production and controlled manufacture technology, in vivo metabolism, excretion, acute and chronic toxicity, etc. In-depth studies in these areas are essential to making DTX nanoformulations applicable in clinic and commercially available viable.
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