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Delay-bounded skyline computing for large-scale real-time online data analytics
Wang, Q;Yu, C;Zhang, YM;Li, HB;Zhong, P
CONCURRENCY AND COMPUTATION-PRACTICE & EXPERIENCE 2017年 29卷10期
EFFICIENT; COMPUTATION
The proliferation of Internet applications, cloud systems, and mobile social networks results in unprecedented data set scale and high data generation rate. For us to be able to extract any meaningful information, it is important to achieve real-time online data analytics. Skyline queries are important in many online data applications such as real-time Web mining, multipreference analysis, and decision making. Most existing studies mainly focus on centralized systems, and distributed skyline query processing is still an emerging and challenging topic. In this paper, we propose SkyStorm, a delay-bounded parallel skyline computing approach for large-scale real-time data analytics by dividing the search into multiple rounds and limiting the search in each round within a budget-restricted range. The effectiveness of our proposals is demonstrated through analysis and simulations.
An Improved and Efficient Process for the Production of Highly Pure Dexmethylphenidate Hydrochloride
Xing, LX;Shen, CW;Sun, YY;Huang, L;Zheng, YY;Li, JQ
JOURNAL OF HETEROCYCLIC CHEMISTRY 2017年 54卷2期 页码:1298-1303
METHYLPHENIDATE; DERIVATIVES
The present work describes an efficient and commercially viable process for the synthesis of dexmethylphenidate hydrochloride (1), a mild nervous system stimulant. The overall yield is 23% with similar to 99.9% purity (including seven chemical steps). Formation and control of possible impurities are also described in this report.
Spleen Stiffness Is Superior to Liver Stiffness for Predicting Esophageal Varices in Chronic Liver Disease: A Meta-Analysis
Ma, XW;Wang, L;Wu, H;Feng, YM;Han, XB;Bu, HR;Zhu, Q
PLOS ONE 2016年 11卷11期 影响因子:3.057
SIGNIFICANT PORTAL-HYPERTENSION; TRANSIENT ELASTOGRAPHY; GASTROESOPHAGEAL VARICES; DIAGNOSTIC-ACCURACY; CIRRHOTIC-PATIENTS; SHEAR-WAVE; NONINVASIVE ASSESSMENT; ARFI ELASTOGRAPHY; HEPATITIS; RISK
Background and Aims;-;Liver stiffness (LS) and spleen stiffness (SS) are two most widely accessible non-invasive parameters for predicting esophageal varices (EV), but the reported accuracy of the two predictors have been inconsistent across studies. This meta-analysis aims to evaluate the diagnostic performance of LS and SS measurement for detecting EV in patients with chronic liver disease (CLD), and compare their accuracy.;-;Methods;-;Pubmed/Medline, Embase, Cochrane Library and Ovid were searched for all studies assessing SS and LS simultaneously in EV diagnosis. A total of 16 studies including 1892 patients were included in this meta-analysis, and the pooled statistical parameters were calculated using the bivariate mixed effects models.;-;Results;-;In detection of any EV, for LS measurement, the summary sensitivity was 0.83 (95% confidence interval [CI]: 0.78-0.87), and the specificity was 0.66 (95% CI: 0.60-0.72). While for SS measurement, the pooled sensitivity and specificity was 0.88 (95% CI: 0.83-0.92) and 0.78 (95% CI: 0.73-0.83). The summary receiver operating characteristic (SROC) curve values of LS and SS were 0.81 (95% CI: 0.77-0.84) and 0.88 (95% CI: 0.85-0.91) respectively, and the results had statistical significance (P<0.01). The diagnostic odds ratio (DOR) of SS (25.73) was significantly higher than that of LS (9.54), with the relative DOR value was 2.48 (95% CI: 1.10-5.60), P<0.05.;-;Conclusions;-;Under current techniques, SS is significantly superior to LS for identifying the presence of EV in patients with CLD. SS measurement may help to select patients for endoscopic screening.
Development of curcumin loaded nanostructured lipid carrier based thermosensitive in situ gel for dermal delivery
Chen, P;Zhang, H;Cheng, SC;Zhai, GX;Shen, CW
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 2016年 506卷 页码:356-362
CHEMOPREVENTIVE AGENT CURCUMIN; SKIN; INFLAMMATION; FUTURE; RAT; EFFICIENCIES; STABILITY; POLOXAMER; BREAKING; SYSTEMS
The objective of this research was to develop novel curcumin-loaded nanostructured lipid carriers (Cur-NLCs) and Cur-NLCs based thermo-sensitive in situ gel (Cur-NLCs-Gel) for topical delivery. Cur-NLCs were prepared using the method of emulsion evaporation-solidification at low temperature and optimized with orthogonal design. The permeation ability of Cur-LNCs and Cur-NLCs-Gel were characterized in vitro. The results showed that the optimized Cur-LNCs represented uniform nano-sized spherical shape with the mean diameter of 263.9 nm. The entrapment efficiency and drug loading were 91.76% and 2.19%, respectively. And there was no significant difference between Cur-NLCs-Gel and Cur-NLCs in morphology, entrapment efficiency and drug loading at the room temperature. The cumulative penetration amount of Cur-NLCs and Cur-NLCs-Gel in vitro were 3,02 times and 2.42 times than that of curcumin propylene glycol solution, respectively. Moreover, in vivo study demonstrated Cur-NLCs-Gel showed the significant anti-inflammatory effect in auricle edemas mice and no obvious irritation to the abdominal skin of rat. Histopathology study of skin showed that Cur-NLCs-Gel could weaken the barrier function of stratum corneum and enhance the permeation of drug into skin. All the evidence showed that NLCs-Gel could provide a promising tuning as a dermal delivery system of curcumin. (C) 2016 Elsevier B.V. All rights reserved.
A meta-analysis of the effects of beta-adrenergic blockers in chronic heart failure
Zhang, XJ;Shen, CW;Zhai, SJ;Liu, YK;Yue, WW;Han, L
EXPERIMENTAL AND THERAPEUTIC MEDICINE 2016年 12卷4期 页码:2489-2496
IDIOPATHIC DILATED CARDIOMYOPATHY; LEFT-VENTRICULAR FUNCTION; RANDOMIZED CONTROLLED-TRIALS; MYOCARDIAL-INFARCTION; CLINICAL-TRIALS; DOUBLE-BLIND; EXERCISE CAPACITY; CARVEDILOL; MORTALITY; BLOCKADE
Adrenergic -blockers are drugs that bind to, but do not activate -adrenergic receptors. Instead they block the actions of -adrenergic agonists and are used for the treatment of various diseases such as cardiac arrhythmias, angina pectoris, myocardial infarction, hypertension, headache, migraines, stress, anxiety, prostate cancer, and heart failure. Several meta-analysis studies have shown that -blockers improve the heart function and reduce the risks of cardiovascular events, rate of mortality, and sudden death through chronic heart failure (CHF) of patients. The present study identified results from recent meta-analyses of -adrenergic blockers and their usefulness in CHF. Databases including Medline/Embase/Cochrane Central Register of Controlled Trials (CENTRAL), and PubMed were searched for the periods May, 1985 to March, 2011 and June, 2013 to August, 2015, and a number of studies identified. Results of those studies showed that use of -blockers was associated with decreased sudden cardiac death in patients with heart failure. However, contradictory results have also been reported. The present meta-analysis aimed to determine the efficacy of -blockers on mortality and morbidity in patients with heart failure. The results showed that mortality was significantly reduced by -blocker treatment prior to the surgery of heart failure patients. The results from the meta-analysis studies showed that -blocker treatment in heart failure patients correlated with a significant decrease in long-term mortality, even in patients that meet one or more exclusion criteria of the MERIT-HF study. In summary, the findings of the current meta-analysis revealed beneficial effects different -blockers have on patients with heart failure or related heart disease.
Prodrug-based nano-drug delivery system for co-encapsulate paclitaxel and carboplatin for lung cancer treatment
Zhang, W;Li, CZ;Shen, CW;Liu, YG;Zhao, XT;Liu, Y;Zou, DN;Gao, ZF;Yue, CW
DRUG DELIVERY 2016年 23卷7期 页码:2575-2580
VINORELBINE PLUS CISPLATIN; PHASE-III; COMBINATION THERAPY; ANTITUMOR EFFICACY; TARGETED DELIVERY; BREAST-CANCER; IN-VIVO; CELL; PLATINUM; CHEMOTHERAPY
Context: Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are major obstacles to the success of chemotherapy in treating cancers.Objective: This study aimed to engineer a prodrug-based nano-drug delivery system for co-encapsulate hydrophilic (CBP) and hydrophobic anti-tumor drugs (PTX). This system was expected to resolve the multidrug resistance cause by single drug, and the dual-drug-loaded liposome was also planned to specifically target the cancer cells without obvious influence on normal cells and tissues.Methods: In this paper, PLGA-PEG-CBP was synthesized by the conjugation between the carboxylic group of PLGA-PEG-COOH and the amino group of CBP. Then, self-assembled nanoparticles for combination delivery of PTX and PLGA-PEG-CBP (PTX/CBP NPs) were prepared by solvent displacement technique. The in vitro and in vivo anti-tumor efficacy was assessed in NCL-H460 human non-small cell lung carcinoma cell line.Results: PTX/CBP NPs achieved the highest cytotoxic effect among all formulations in vitro, as compared with single drug delivery NPs. In vivo investigation on NSCLC animal models showed that co-delivery of PTX and CBP possessed high tumor-targeting capacity and strong anti-tumor activity.Conclusions: The PTX/CBP NPs constructed in this research offers an effective strategy for targeted combinational lung cancer therapy.
A pharmacokinetic study of Isatin in Beagles' bodies
Ren, AL;Su, BH;Ye, SY;Wei, X;Fang, ZG;Wang, Q;Zhang, J;Xu, W;Yue, W;Yin, L;Liu, ZT;Li, XL;Ding, B
EXPERIMENTAL AND THERAPEUTIC MEDICINE 2016年 11卷6期 页码:2225-2228
INHIBITOR
Isatin are marine active drugs that exert anti-cancer effects, have a cancer-prevention function, and possess many pharmacological activities. The study aimed to examine the pharmacokinetics of a single intravenous injection and oral medication of Isatin given to Beagles. Nine male and nine female Beagles were injected with 30 mg/kg of 2,3-indole quinones. The animals were divided into 3 groups (n=6 per group) and lavaged with a dose of 15, 30 and 60 mg/kg, respectively. Blood samples were collected prior to the medicine delivery (0 h) and 0.083, 0.25, 0.5, 1, 2, 4, 6, 8 and 24 h post-medicine delivery. The blood plasma samples were analyzed using the liquid chromatography-mass spectrometry (MS)/MS method following pretreatment for the protein precipitation. Pharmacokinetics software was applied to calculate relevant pharmacokinetic parameters through the atrioventricular model. The drug concentration in plasma decreased rapidly following the intravenous injection of Isatin. After 8 h, the prototype drugs could not be tested in the plasma and only trace amounts of drugs were tested in one dog, which was considered to be an endogenous drug. Indole quinone was absorbed following lavage into Beagles and peaked in <1 h, and the drug concentration in the plasma decreased rapidly. After 8 h, the prototype drugs could not be tested in the plasma. The elimination of the two drugs in the body had no evident gender differences. In conclusion, Isatin is rapidly absorbed in bodies of Beagles. Within the dose range of 15-60 mg/kg, no linear relationship was observed for the increase in Cmax and AUC(0-t) values with the increased dose.
Design, synthesis and biological evaluation of novel dicarbonylalkyl piperazine derivatives as neuroprotective agents
Wang, WY;Shen, CW;Weng, ZJ;Wang, TC;Zhang, C;Jin, XQ;Li, JQ
CHINESE CHEMICAL LETTERS 2016年 27卷3期 页码:387-390
ACUTE ISCHEMIC-STROKE; INJURY; DL-3-N-BUTYLPHTHALIDE; EDARAVONE; PENUMBRA; UPDATE
In the search of novel neuroprotective agents with higher potency than our previously identified anti-ischemic stroke drug candidate 1, a series of novel dicarbonyl piperazine derivatives were synthesized and evaluated on their neuroprotective activity via oxygen-glucose deprivation test in the neuron-like PC12 cells, hypoxia tolerance model in mice and focal cerebral ischemia model in rats. The result obtained indicated that compounds 7f, 7k and 7o, exhibited neuroprotective activity. Particularly, compound 7o containing 2,5-dimethylpiperazin moiety, showed prolonged life time of mice and reduced cerebral infarction of rats, which provided a potential candidate for the development of neuroprotective agents. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
Farrerol inhibits IL-6 and IL-8 production in LPS-stimulated human gingival fibroblasts by suppressing PI3K/AKT/NF-kappa B signaling pathway
Wang, Q;Zhang, B;Yu, JL
ARCHIVES OF ORAL BIOLOGY 2016年 62卷 页码:28-32
NF-KAPPA-B; PORPHYROMONAS-GINGIVALIS; PERIODONTAL-DISEASE; EPITHELIAL-CELLS; EXPRESSION; LIPOPOLYSACCHARIDE; MEDIATORS; RESPONSES
Objectives: Farrerol, a new type of 2,3-dihydro-flavonoid isolated from rhododendron, has been shown to have anti-bacterial and anti-inflammatory activities. In the present study, we investigated the anti-inflammatory effects of farrerol on the production of IL-6 and IL-8 in human gingival fibroblasts (HGFs) treated with lipopolysaccharide (LPS).;-;Methods: The cytotoxicity of farrerol was determined using the MTT assay. The production of IL-6 and IL-8 was measured using ELISA and qRT-PCR. The effects of farrerol on PI3K, Akt phosphorylation, and NF-kappa B activation were detected using western blotting analyses.;-;Results: These results showed that farrerol inhibited LPS-induced IL-6 and IL-8 production in a dose dependent manner. LPS-induced NF-kappa B activation was suppressed by farrerol. Furthermore, farrerol suppressed LPS-induced PI3K and Akt phosphorylation, which are upstream molecules of NF-kappa B.;-;Conclusion: These results indicated that farrerol attenuated IL-6 and IL-8 production by inhibition of PI3K and AKT phosphorylation, resulting in an inhibition of NF-kappa B activation. Farrerol may be a therapeutic agent for the treatment of periodontal disease. (C) 2015 Elsevier Ltd. All rights reserved.
New synthesis route for the preparation of pomalidomide
Huang, DW;Shen, CW;Wang, WY;Huang, L;Ni, F;Li, JQ
SYNTHETIC COMMUNICATIONS 2016年 46卷16期 页码:1343-1348
REFRACTORY MULTIPLE-MYELOMA; THALIDOMIDE
A new route for the preparation of pomalidomide is described in the study. The synthetic procedure starts from 4-nitroisobenzofuran-1,3-dione and 3-aminopiperidine-2,6-dione hydrochloride via a three-step reaction resulting in a total yield of 65% with a high-performance liquid chromatographic (HPLC) purity of 99.56% and a low palladium residue level of 2ppm. This method can be deemed as an efficient, practical, and environmentally friendly synthetic route for the preparation of pomalidomide.;-;[GRAPHICS];-;.
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