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Comparison of nerve combing and percutaneous radiofrequency thermocoagulation in the treatment for idiopathic trigeminal neuralgia
Zhou, XC;Liu, YQ;Yue, ZY;Luan, DH;Zhang, H;Han, J
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY 2016年 82卷5期 页码:574-579
MICROVASCULAR DECOMPRESSION; COMPRESSION; MANAGEMENT; RHIZOTOMY; GANGLION; ROOTLETS
Introduction: Idiopathic trigeminal neuralgia (ITN) is a common pain disease in elderly people. Many methods have been used to alleviate the pain of patients, but few studies in the literature have compared the effect of nerve combing and percutaneous radiofrequency thermocoagulation.;-;Objective: The purpose of this study was to describe and evaluate the clinical outcome of idiopathic trigeminal neuralgia after nerve combing (NC) and compare them with those obtained using percutaneous radiofrequency thermocoagulation (RF).;-;Methods: The study included 105 idiopathic trigeminal neuralgia patients with similar symptom, age and underlying disease, which were divided into two groups. One group was treated by nerve combing (50 patients), the other by RF (55 cases). All patients were considered medical failures prior to the surgeries. A questionnaire was used to assess the long-term outcomes: pain relief, recurrence, complication and need for additional treatment.;-;Results: The median duration of follow-up in both groups was 90 months. Satisfactory relief was noted in 41 patients (82%), 5 patients (10%) initially experienced pain relief, then recurred, and four patients (8%) were designated poor among the group NC. In the group RF, satisfactory relief was noted in 42 patients (76.4%). There were eight "pain free with recurrence patients (14.5%) and 5 poor cases (9.1%). No statistically significant differences existed in the outcomes between both groups (p>0.05). Postoperative morbidity included dysesthesia, diplopia, partial facial nerve palsy, hearing loss, tinnitus, cerebrospinal fluid leak, meningitis and mortality.;-;Conclusion: Nerve combing and RF are both satisfactory treatment strategies for patients with ITN. Because of the higher risk of sensory morbidity and surgical risk as open surgery, RF is preferred as the recommended procedure for patients with ITN. (C) 2015 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Surgical management of facial paralysis resulting from temporal bone fractures
Liu, YQ;Han, J;Zhou, XC;Gao, K;Luan, DH;Xie, FY;Wang, XT;Zong, GX;Ding, L
ACTA OTO-LARYNGOLOGICA 2014年 134卷6期 页码:656-660
DECOMPRESSION SURGERY; NERVE PARALYSIS; OUTCOMES; PALSY
Conclusion: To achieve good facial reanimation in cases with facial paralysis resulting from temporal bone fractures, the ideal timing for surgical intervention is at least within 1 month of injury and an appropriate surgical approach should be selected depending on the site of facial nerve injury. Objective: This paper aimed to address the ideal time for surgical intervention and the appropriate surgical approach for patients with facial paralysis resulting from temporal bone fractures. Methods: We retrospectively investigated 60 patients with facial paralysis due to temporal bone fractures who underwent facial nerve decompression via different operative approaches within 1 month after trauma, of which 48 were surgically treated by the middle cranial fossa approach (80%), 8 by a pure transmastoid approach (13.3%), and four by a combined transmastoid and middle cranial fossa approach (6.7%). The House-Brackmann (H-B) grading system was used to evaluate the recovery of facial nerve function. Results: The follow-up period for all the patients was 1 year. Among 60 patients who were surgically treated, 39 achieved grade I of facial nerve function, 18 achieved grade II, two achieved grade III, and one achieved grade IV according to the H-B grading system.
The long-term outcome of nerve combing for trigeminal neuralgia
Han, J;Zhou, XC;Luan, DH;Gao, K;Xie, FY;Cheng, X;Wang, XT;Zong, GX;Liu, YQ
ACTA NEUROCHIRURGICA 2013年 155卷9期 页码:1703-1708
RETROGASSERIAN GLYCEROL RHIZOTOMY; MICROVASCULAR DECOMPRESSION; VASCULAR COMPRESSION; CONSECUTIVE PATIENTS; NEUROVASCULAR COMPRESSION; MULTIPLE-SCLEROSIS; SERIES
The purpose of our study was to describe and evaluate the long-term clinical outcome of nerve combing for idiopathic trigeminal neuralgia (TN) with and without vascular compression.;-;The study included 60 trigeminal neuralgia patients, 28 of which (Group A) had no visible vascular compression intraoperatively and 32 of which (Group B) had trigeminal nerve root entry zone (REZ) compressed by vascular structure. All patients were considered medical failures prior to the surgeries. All of them underwent trigeminal nerve combing. The following outcome measures were assessed: pain relief, recurrence, complication and time to pain relief.;-;The median duration of follow-up was 52 months (range 48-96 months) in group A and 56 months (range 48-96 months) in group B. Excellent relief and good relief were noted in 23 patients (82.1 %) and two patients (7.1 %) from group A, respectively, and in 20 (62.5 %) and eight patients (25 %) from group B. The major complication of both groups was facial numbness. And the total complication rate was 15.8 % in group A and 18.8 % in group B. Recurrence was found in one patient in group A and in two in group B by the end of follow-up.;-;Trigeminal nerve combing is effective in treating TN, but has a much higher pain relief rate in patients without vascular compression than those with vascular compression.
Alteration of discoidin domain receptor-2 expression: possible role in peroxynitrite-induced apoptosis in human cerebral vascular smooth muscle cells
Li, L;Yue, ZY;Wan, XJ;Zhang, GD;Song, SS;Bai, XH;Jiao, YL;Ju, YR;Li, JF
MOLECULAR & CELLULAR TOXICOLOGY 2012年 8卷4期 页码:401-406
NITRIC-OXIDE; SUPEROXIDE; COLLAGEN; DISEASES; ACTIVATION; OXYGEN
Peroxynitrite(ONOO-), a product of nitric oxide and superoxide anion interaction, is a powerful and versatile oxidant. In this work, the human cerebral vascular smooth muscle cells (HCVSMCs) were cultured in vitro and subjected to different concentrations of ONOO-. Cell viability and morphological changes were measured by methylthiazoletetrazolium (MTT) assay and Ho33342/PI double staining respectively. The apoptotic rate was assessed by flow cytometry. The alterations in the expression of DDR2 at both mRNA and protein levels were examined by real-time PCR and Western-blot simultaneously. Direct exposure of HCVSMCs to ONOO- was able to inhibit the cell proliferation, which was further revealed via the apoptotic pathway. ONOO- exerted a dual-effect on DDR2 expression at both mRNA and protein levels that depended on the concentrations of ONOO-. Our results demonstrate for the first time that DDR2 gene may play an important role in ONOO--induced apoptosis in HCVSMCs.
Peroxynitrite-induced apoptosis in human brain vascular smooth muscle cells is associated with induction of PDCD4 gene expression.
Li, Y;Li, L;Jiao, YL;Xu, CY;Zhang, GD;Liu, WW;Yue, ZY;Li, JF
BIOMEDICAL RESEARCH-INDIA 2012年 23卷4期 页码:597-603
NITRIC-OXIDE
The present study investigated whether peroxynitrite (ONOO-)-elicited cytotoxicity on human brain vessel smooth muscle cells (HBVSMCs) was related to alteration in programmed cell death 4 (PDCD4) gene expression. Cell viability, morphological changes and apoptosis were determined by_methylthiazoletetrazolium (MTT) assay, acridine orange staining and flow cytometry, respectively. Expressions of PDCD4 at both mRNA and protein levels were examined by RT-PCR and Western blot respectively. Protein expressions of caspase-3, Bcl-2 and Bax were detected by Western an increased apoptotic rate of HBVSMCs after treatment with ONOO-. ONOO- was able to upregulate mRNA and protein expressions of the PDCD4 gene. Moreover, protein expressions of caspase-3 and Bax were significantly increased, whereas the expression of Bcl-2 was markedly decreased in response to exposure of ONOO-. This study demonstrates, for the first time, that the PDCD4 gene is involved in ONOO- induced apoptosis in HBVSMCs.
Peroxynitrite-Induced Apoptosis in FaDu Cells is Correlated with the Up-Regulation of PDCD4 Gene
Song, SS;He, MQ;Li, L;Zhang, GD;Liu, WW;Bai, XH;Wang, HB;Yue, ZY;Li, JF
LATIN AMERICAN JOURNAL OF PHARMACY 2012年 31卷2期 页码:220-225
NITRIC-OXIDE; INHIBITS TRANSLATION; SUPPRESSOR PDCD4; CANCER-CELLS; DEATH; EXPRESSION; PROTEIN; INITIATION; INDUCTION; BINDING
Peroxynitrite (ONOO-) is a highly reactive species that attacks a range of biological targets. The present study was designed to investigate the effect of ONOO- on FaDu cells, a human hypopharyngeal cancer cell line, with special attention given to the PDCD4 gene expression in response to this oxidative stress. The in vitro cultured FaDu cells were subjected to various concentrations of ONOO-, then, the cell viability and morphological changes were examined by MTT assay and acridine orange staining, respectively. The protein expressions of Caspase-9, Caspase-3, and PDCD4 were determined by western blot and the mRNA expression of PDCD4 was analyzed by RT-PCR. This work demonstrated that ONOO- could inhibit the proliferation and induce apoptosis of FaDu cells. The protein expressions of Caspase-9, Caspase-3, and PDCD4 were up-regulated and, meanwhile, the mRNA expression of PDCD4 was increased, in response to ONOO-. These data suggest that ONOO- can effectively suppress proliferation of FaDu cells via triggering the apoptotic pathway. PDCD4 gene may play an important role in ONOO--induced apoptosis in FaDu cells, which may offer a new target for the treatment of hypopharyngeal carcinoma.
Secretion of antidiuretic hormone in children with obstructive sleep apnea-hypopnea syndrome
Yue, ZY;Wang, MM;Xu, W;Li, H;Wang, HB
ACTA OTO-LARYNGOLOGICA 2009年 129卷8期 页码:867-871
BLOOD-PRESSURE
Conclusions: Obstructive sleep apnea-hypopnea syndrome (OSAHS) in children with hypoxemia might influence the nocturnal secretion of antidiuretic hormone (ADH) that is associated with polyuria, even nocturia. Objective: The impact of OSAHS on the secretion levels of ADH was studied in pediatric patients with adenotonsillar hypertrophy. Subjects and methods: Forty-eight children (28 with OSAHS, 20 as normal controls) were recruited in this study. Respiratory indexes of all subjects were monitored by polysomnography and 12-h urinary volume was recorded during sleep. Vein blood was sampled to detect the levels of ADH in serum using a radioimmunoassay technique, both before and after adenotonsillectomy. Results: After surgery for OSAHS, the mean value of the apnea-hypopnea index (AHI) decreased (from 17.36 +/- 2.61 to 3.32 +/- 1.41, p<0.001), lowest arterial oxygen saturation (LSaO(2)) increased (from 78.34 +/- 13.44 to 95.35 +/- 6.24, p<0.001), urine volume (UV) in nocturnal 12 h reduced (from 492 +/- 90 to 332 +/- 56, p<0.001), and ADH level increased (from 63.08 +/- 35.15 to 83.10 +/- 21.05, p<0.05). The differences in UV and ADH between postoperative children and healthy controls were not statistically significant (both p>0.05).
Superantigens and the expression of T-cell receptor repertoire in chronic rhinosinusitis with nasal polyps
Wang, M;Shi, P;Yue, Z;Chen, B;Zhang, H;Zhang, D;Wang, H
ACTA OTO-LARYNGOLOGICA 2008年 128卷8期 页码:901-908
STAPHYLOCOCCAL EXOTOXINS; PATHOGENESIS; HYPOTHESIS; SINUSITIS; DISEASE; IGE
Conclusions. Staphylococcal exotoxins (SEs), acting as superantigens, activate the beta variable chains of T-cell receptors (TCRV beta) with subsequent massive proliferation and corresponding excursion of gene spectra, thereby contributing to the etiology of chronic rhinosinusitis with nasal polyps (CRSwNP). Objectives. To demonstrate the presence of SEs in sinonasal mucosa, and determine the effect of superantigens on the T cells expressing the target of superantigen, i.e. TCRV beta in patients with CRSwNP. Materials and methods. Nasal mucosa and sinonasal polyp tissue specimens were obtained from 37 patients with CRS (22 with bilateral nasal polyps, 15 without nasal polyps). Specimens were assayed by enzyme-linked immunosorbent assay (ELISA) for SEs (SEA, SEB, SEC, SED) and toxic shock syndrome toxin type-1 (TSST-1), and analyzed by flow cytometry and reverse transcriptase-polymerase chain reaction (RT-PCR), respectively, to determine the expression of TCRV beta repertoire. Results. In the CRSwNP subjects 12 of 22 samples (54.54%) demonstrated reactivity for staphylococcal exotoxins. There was no positive result in the CRS without nasal polyps or normal control group. There was a high percentage of V beta(+) T cells in the superantigen-positive group. The expressional intensity of V beta 3, 14, 15, 17, and 20 was specifically enhanced in SEB-positive subjects, as well as that of V beta 2 and 6.1-3 in specimens that were TSST-1-positive compared with those that were negative for superantigens (all p<0.05). There were no dominantly expressed V beta fragments in ELISA-negative specimens.
Continuous Positive Airway Pressure Effectively Alleviates Arrhythmias in Patients with Obstructive Sleep Apnea: Possible Relationship with Counteracting Oxidative Stress
Wang, XT;Zhao, G;Tu, L;Yue, ZY;Liu, ZH;Han, J;Gao, K;Zhou, XC;Xu, S;Li, JF
CURRENT MEDICAL SCIENCE 2019年 39卷1期 页码:52-58
INTERMITTENT HYPOXIA; CPAP; MODERATE; ASSOCIATION; THERAPY
This work is aimed at exploring the clinical efficacy of continuous positive airway pressure (CPAP) in treatment of patients with arrhythmias combined with obstructive sleep apnea (OSA). Through evaluating serum native thiol, malonaldehyde (MDA) and nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) in these patients and describing the effects on oxidative parameters of CPAP therapy for 3 months, we confirmed the impact of oxidative stress on arrhythmias. A total of 64 patients with OSA combined with arrhythmias were collected from April 2014 to April 2017 with full clinical information. Patients were divided into two groups (paired experiment design): 32 patients in group A (control group), who received unchanged anti-arrhythmia treatment and 32 patients in group B, who were subjected to unchanged pharmacological anti-arrhythmia therapy combined with CPAP. OSA related parameters were compared between the two groups after 3-month therapy. And the levels of parameters of oxidative stress in patients were measured before and after CPAP therapy. After 3 months of CPAP therapy, compared with the control group, the percentage of sage N3 (NREM 3) and stage R (REM) in total sleep time was significantly increased, while apnea-hypopnea index (AHI) and the Epworth Sleepiness Scale (ESS) score were evidently decreased. Meanwhile, the lowest oxygen saturation (LSpO(2)) was also elevated after CPAP treatment for 3 months. The CPAP therapy significantly prevented the occurrence of arrhythmias (P<0.05). Both the MDA level and NADPH oxidase levels were significantly lower in the group B than in the group A (P<0.05). But serum native thiol was improved by CPAP treatment (P<0.05). In conclusion, proper use of CPAP therapy provides significant benefits for the treatment of arrhythmia in patients with OSA.
Analysis of related factors of recurrence in horizontal semicircular canal benign paroxysmal positional vertigo: a pilot study
Ding, L; Lin, T; Zhou, XC; Han, J; Xu, AT
ACTA OTO-LARYNGOLOGICA 2020年 140卷1期 页码:8-13
RESIDUAL DIZZINESS
Background: Whether the abnormal caloric test (C-test) affects recurrence rate in horizontal semicircular canal benign paroxysmal positional vertigo (HSC-BPPV) with residual dizziness (RD) is not clear. Objectives: 1) Analyze the association of the cycles of canalith repositioning procedure (CRP), C-test and RD after CRP and 2) determine which affects the recurrence rate in idiopathic HSC-BPPV. Materials and methods: Eighty-four patients with HSC-BPPV (canal type) were included in this work. The cycles of CRP, C-test, the RD after CRP and HSC-BPPV recurrence rate were recorded. Depending on the times of CRP and patients who presented dizziness after treatment, patients were divided into four groups, the relationship between abnormal C-test and RD was analyzed. The outcomes of recurrence rate were compared between groups, respectively. Results: (1) The abnormal C-test prevalence among the HSC-BPPV patients with RD was 36% while in no RD group was 14.7%. The difference was statistically significant (p = .045). (2) The recurrence rate was 11.8% in no RD group but in RD group the rate was higher (32%, p = .039). When patients combined with abnormal C-test, the recurrence rate was significantly higher (77.8% vs. 20%) (p = .033). Conclusions: A weak correlation between RD and abnormal C-test is noted. Presence of RD and abnormal C-test in patients with HSC-BPPV predicts a higher recurrence rate.
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