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Cytokine Responses to Specific Immunotherapy in House Dust Mite-Induced Allergic Rhinitis Patients
Li, H;Xu, EX;He, MQ
INFLAMMATION 2015年 38卷6期 页码:2216-2223 影响因子:2.618
SUBLINGUAL-SWALLOW IMMUNOTHERAPY; DOUBLE-BLIND; COMPLEMENT ACTIVATION; RESPIRATORY ALLERGY; ASTHMA; CELLS; METAANALYSIS; INTERLEUKIN-17; ANAPHYLATOXINS; SEVERITY
Allergen-specific immunotherapy is the only immunomodulatory treatment that may alter the natural course of allergic disease. However, cytokine responses accompanying sublingual immunotherapy (SLIT) responder phenotypes have not been fully understood. Herein, we examined the level of crucial plasma cytokines during SLIT and evaluated whether their changes correlated to symptom scores. We observed that the levels of interleukin (IL)-17 and complement components C3a and C5a as well as IL-4 at year 3 of SLIT were significantly decreased than those at baseline. In contrast, there was no significant difference in the levels of IL-5, IL-13, and interferon (IFN)-gamma. Notably, a significant positive correlation was found between the levels of IL-17 and the symptom scores at year 3. These results suggest that IL-17 could be considered a potential biomarker for the therapeutic effect of SLIT in allergic rhinitis caused by house dust mite.
优质护理管理在静脉治疗患者中的应用
孟丽; 刘新; 尹鹤
齐鲁护理杂志 2023年 29卷15期 页码:49-52 影响因子:0.867
优质护理管理;静脉治疗;护理质量;安全性
目的:探讨优质护理管理在静脉治疗患者中的应用效果。方法:选择2021年6月1日~2022年6月1日在住院部接受静脉治疗的患者134例,随机分为对照组和实验组各67例,对照组实行常规静脉治疗护理,实验组实行静脉治疗优质护理管理;比较两组护理满意度,护理质量,干预前后心理状态[采用焦虑自评量表(SAS)、抑郁自评量表(SDS)],不良事件发生情况及穿刺成功率。结果:实验组护理满意度高于对照组(P<0.01),就诊环境、护士行为、服务态度、操作技术评分及总分均高于对照组(P<0.01);护理后,实验组SAS、SDS评分均低于对照组(P<0.01);实验组不良事件发生率低于对照组(P<0.01);实验组穿刺成功率高于对照组(P<0.05,P<0.01)。结论:优质护理管理在静脉治疗患者中的应用效果满意,可有效提高护理人员的护理质量和静脉治疗安全性,具备一定推广意义。
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