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短期应用血脂康对经皮冠状动脉介入围手术期血浆C反应蛋白水平的影响
刘继东;刘尊齐;崔连群;王勇;孔庆赞;郭拥军;唐元升
中华心血管病杂志 2006年 34卷5期 页码:406-406页,共1页 影响因子:2.808
骨髓间充质细胞静脉移植减轻大鼠颈动脉球囊损伤后内膜增生
刘继东;崔连群;张欣;李锋;盖玉生
药物生物技术 2006年 13卷6期 页码:456-459页,共4页 影响因子:0.473
骨髓间充质细胞;移植;内皮;损伤;颈动脉
探讨骨髓间充质细胞(BM-MSCs)静脉移植对大鼠颈总动脉球囊损伤后再内皮化和内膜增生的影响.38只Wistar大鼠行颈总动脉球囊损伤后随机分为2组:移植组(n=16)给静脉移植1×106个(置于1 ml生理盐水中)预先培养的BM-MSCs,术后7 d、28 d分别取材,用电镜、HE染色、免疫组织化学方法观察血管再内皮化及新生内膜增生情况.对照组(n=16)用生理盐水代替BM-MSCs静脉注入,其余同移植组.移植组增殖细胞核抗原(PCNA)阳性率显著低于对照组(P<0.05),白细胞表面分化抗原(CD)34阳性率则明显升高(P<0.05),且随时间增加更加明显(P<0.05).移植组在7 d、28 d内膜/中膜面积比(I/M ratio)显著低于对照组(P<0.05).BM-MSCs静脉移植可以显著促进球囊损伤后血管内皮化,抑制内膜过度增生.
自制微导管自体骨髓单个核细胞移植治疗急性心肌梗死
刘继东;崔连群;张欣;盖玉生;李锋
药物生物技术 2006年 13卷5期 影响因子:0.473
急性心肌梗死;经皮冠脉介入治疗;骨髓单个核细胞;移植
用自制的微导管给予冠脉内骨髓单个核细胞(BM-MNCs)移植(bone marrow stem cells heart transplantation BMT),观察对急性心肌梗死患者心肌梗死面积及心功能的疗效.将24例首次心梗的患者随机分为2组,经皮冠脉介入治疗(PCI)组(n=12)给急症PCI及常规药物治疗,BMT组(n=12),急症PCI同时经自制的微导管给予自体BM-MNCs冠脉移植,分别于出院前、3月、6月时用Tei指数评价心功能,铊201(201Tl)静息-再分布显像观察心梗面积.结果:3月时2组患者Tei指数均降低(3月vs出院前,移植组0.45±0.09 vs0.67±0.12,P<0.05;对照组:0.55±0.08 vs 0.67±0.06,P<0.05),移植组较对照组更明显(0.45±0.09 vs0.55±0.08,P<0.05),至6月时无明显变化;3月时移植组心梗面积较出院前明显减少(15.10±3.34 vs22.95±5.94,P<0.05),至6月时无明显变化.与对照组相比均显著减少(3月:15.10±3.34 vs 19.85±4.09;6月:13.70±3.10 vs 17.66±4.70,P均<0.05).结论:自制的微导管给予冠脉内BM-MNCs移植治疗AMI能减小心肌梗死的范围,改善心功能.
阿托伐他汀快速降低老年不稳定性心绞痛患者血清炎症因子浓度
刘继东;崔连群;刘尊齐;王晓军;李锋;盖玉生;郭拥军;孔庆赞;赵传艳
中华心血管病杂志 2006年 34卷10期 页码:942-942页,共1页 影响因子:2.808
自制微导管自体骨髓单个核细胞移植治疗急性心肌梗死
刘继东;崔连群;张欣;盖玉生;李锋'
药物生物技术 2006年 13卷5期 页码:366-369页,共4页 影响因子:0.473
急性心肌梗死;经皮冠脉介入治疗;骨髓单个核细胞;移植
用自制的微导管给予冠脉内骨髓单个核细胞(BM-MNCs)移植(bone marrow stem cells heart transplantation BMT),观察对急性心肌梗死患者心肌梗死面积及心功能的疗效。将24例首次心梗的患者随机分为2组,经皮冠脉介入治疗(PCI)组(n=12)给急症PCI及常规药物治疗,BMT组(n=12),急症PCI同时经自制的微导管给予自体BM-MNCs冠脉移植,分别于出院前、3月、6月时用Tei指数评价心功能,铊201(^201TI)静息-再分布显像观察心梗面积。结果:3月时2组患者Tei指数均降低(3月vs出院前,移植组0.45±0.09V80.67±0.12,P<0.05;对照组:0.55±0.08vs0.67±0.06,P<0.05),移植组较对照组更明显(0.450.±09vs0.55±0.08,P<0.05),至6月时无明显变化;3月时移植组心梗面积较出院前明显减少(15.10±3.34vs22.95±5.94,P<0.05),至6月时无明显变化。与对照组相比均显著减少(3月:15.10±3.34vs19.85±4.09;6月:13.70±3.10vs17.66±4.70,P均<0.05)。结论:自制的微导管给予冠脉内BM-MNCs移植治疗AMI能减小心肌梗死的范围,改善心功能。
Emergence of NDM-1-and CTX-M-3-Producing Raoultella ornithinolytica in Human Gut Microbiota
Wang, S; Xu, LC; Chi, XH; Li, Y; Kou, ZQ; Hou, PB; Xie, HJ; Bi, ZW; Zheng, BW
FRONTIERS IN MICROBIOLOGY 2019年 10卷
LACTAMASE-PRODUCING ENTEROBACTERIACEAE; ESCHERICHIA-COLI; BETA-LACTAMASES; KLEBSIELLA; PNEUMONIAE; CTX-M-14; KPC-2
Raoultella ornithinolytica is an opportunistic pathogen of the Enterobacteriaceae family and has been implicated in nosocomial infections in recent years. The aim of this study was to characterize a carbapenemase-producing R. ornithinolytica isolate and three extended-spectrum beta-lactamase (ESBL)-producing R. ornithinolytica isolates from stool samples of adults in a rural area of Shandong Province, China. The species were identified using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and 16S rDNA sequence analysis. Antimicrobial susceptibility test showed that all four isolates were multidrug-resistant (MDR). The whole genome sequence (WGS) of these isolates was determined using an Illumina HiSeq platform, which revealed MDR-related genes. The S1 nuclease-pulsed-field gel electrophoresis (S1-PFGE) was used to characterize the plasmids carried by the R. ornithinolytica isolates. The bla(NDM-1) and bla(CTX-M-3) genes were probed using Southern blotting, which confirmed the location of both genes on the same plasmid with molecular weight of 336.5-398.4 kb. The transferability of bla(NDM-1) and bla(CTX-M) was also confirmed by conjugation assays. Finally, BLAST analysis of both genes showed that mobile genetic elements were associated with the spread of drug resistance genes. Taken together, we report the presence of conjugative bla(NDM-1) and bla(CTX-M) plasmids in R. ornithinolytica isolates from healthy humans, which indicate the possibility of inter-species transfer of drug resistance genes. To the best of our knowledge, this is the first study to isolate and characterize carbapenemase-producing R. ornithinolytica and ESBL-producing R. ornithinolytica isolates from healthy human hosts.
BRCA GENETIC STATUS DOES IMPACT THE TOXICITY OF RARP INHIBITORS IN PATIENTS WITH EPITHELIAL OVARIAN CANCER
Li, HQ; Gao, YW; Zhang, TG; Gai, MX; Zhang, HY
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 2022年 32卷 页码:A155-
Inverse association between caffeine intake and albuminuria in US adults: an analysis of NHANES 2005-2016
Ma, QQ; Song, SH; Xu, GS
ACTA CLINICA BELGICA 2023年 页码:-null
无关键词信息
ObjectivesAlbuminuria is a significant biomarker of various kidney diseases and is associated with renal outcome. Recently, caffeine intake has shown potential renoprotective effects. However, the relationship between caffeine intake and albuminuria remains profoundly elusive.MethodsWe conducted a cross-sectional study aimed to explore the association between caffeine intake and albuminuria in the American adult population using the data acquired from the National Health and Nutrition Examination Survey (NHANES) 2005-2016. Caffeine intake was assessed by 24-h dietary recalls, and albuminuria was assessed by albumin-to-creatinine ratio. Multivariate logistic regression was performed to explore the independent association between caffeine intake and albuminuria. Subgroup analysis and interaction tests were also conducted.ResultsAmong 23,060 participants, 11.8% of the individuals exhibited albuminuria, and the prevalence of albuminuria decreased with higher caffeine intake tertiles (Tertile 1: 13%; Tertile 2: 11.9%; Tertile 3: 10.5%; P < 0.001). After adjusted potential confounders, the results of logistic regression indicated that a higher caffeine intake was associated with a decreased risk of albuminuria (OR = 0.903; 95% CI: 0.84, 0.97; P = 0.007), especially in females and the participants aged ConclusionThe present study first indicated an inverse correlation between caffeine intake and albuminuria, which further confirmed the potentially protective effects of caffeine on the kidney.
The plant nuclear lamina disassembles to regulate genome folding in stress conditions
Wang, N; Wang, ZD; Tzourtzou, S; Wang, X; Bi, XL; Leimeister, J; Xu, LH; Sakamoto, T; Matsunaga, S; Schaller, A; Jiang, H; Liu, C
NATURE PLANTS 2023年 页码:-null
无关键词信息
The nuclear lamina is a complex network of nuclear lamins and lamin-associated nuclear membrane proteins, which scaffold the nucleus to maintain structural integrity. In Arabidopsis thaliana, nuclear matrix constituent proteins (NMCPs) are essential components of the nuclear lamina and are required to maintain the structural integrity of the nucleus and specific perinuclear chromatin anchoring. At the nuclear periphery, suppressed chromatin overlapping with repetitive sequences and inactive protein-coding genes are enriched. At a chromosomal level, plant chromatin organization in interphase nuclei is flexible and responds to various developmental cues and environmental stimuli. On the basis of these observations in Arabidopsis, and given the role of NMCP genes (CRWN1 and CRWN4) in organizing chromatin positioning at the nuclear periphery, one can expect considerable changes in chromatin-nuclear lamina interactions when the global chromatin organization patterns are being altered in plants. Here we report the highly flexible nature of the plant nuclear lamina, which disassembles substantially under various stress conditions. Focusing on heat stress, we reveal that chromatin domains, initially tethered to the nuclear envelope, remain largely associated with CRWN1 and become scattered in the inner nuclear space. By investigating the three-dimensional chromatin contact network, we further reveal that CRWN1 proteins play a structural role in shaping the changes in genome folding under heat stress. Also, CRWN1 acts as a negative transcriptional coregulator to modulate the shift of the plant transcriptome profile in response to heat stress. The nuclear lamina in Arabidopsis, a protein meshwork beneath the nuclear envelope, disassembles under various abiotic stresses, modulating changes in three-dimensional genome organization and gene transcription in stress response.
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